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首页> 外文期刊>International Journal of Electrochemical Science >Investigation of the Interaction between Ferroceneboronic Acid and Sugars and Its Application in Probing of Enzyme Activity
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Investigation of the Interaction between Ferroceneboronic Acid and Sugars and Its Application in Probing of Enzyme Activity

机译：二茂铁硼酸与糖的相互作用及其在酶活性检测中的应用研究

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摘要

Sugars play important roles in many biological processes, such as nutrition, metabolism, cell structureformation, and immunological protection. Phenylboronic acid (PBA) derivatives have been widelyused as recognition molecules for sugars based on the formation of boronate ester bonds betweenboronic acid and 1,2-diol or 1,3-diol of sugars. In this work, ferroceneboronic acid (FBA, anelectrochemically active ferrocene derivative) was used to investigate the interaction between boronicacid and phosphated as well as non-phosphated sugars. Based on the difference in the voltammetricresponses of the complexes between FBA and examined sugars, FBA probe was used to monitor theactivity of enzymes, such as phosphoglucose isomerase (PGI) and alkaline phosphatase (ALP). Thiswork would be valuable for understanding of the diol-boronate interaction and screening of newenzyme inhibitors.
机译：糖在许多生物过程中发挥重要作用，例如营养，代谢，细胞结构形成和免疫保护。基于硼酸与糖的1,2-二醇或1,3-二醇之间形成硼酸酯键，苯硼酸（PBA）衍生物已被广泛用作糖的识别分子。在这项工作中，二茂铁硼酸（FBA，一种具有电化学活性的二茂铁衍生物）用于研究硼酸与磷酸化和非磷酸化糖之间的相互作用。根据FBA和所检查的糖之间的伏安响应的差异，FBA探针用于监测酶的活性，例如磷酸葡萄糖异构酶（PGI）和碱性磷酸酶（ALP）。这项工作对于理解二醇-硼酸酯相互作用和筛选新酶抑制剂将是有价值的。

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