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首页> 外文期刊>International Journal of Electrochemical Science >Study on the Cr3+-Induced Ion Channel Based the Electron Transfer Rate Across Mimic Biomembrane Measured by Scanning Electrochemical Microscopy
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Study on the Cr3+-Induced Ion Channel Based the Electron Transfer Rate Across Mimic Biomembrane Measured by Scanning Electrochemical Microscopy

机译：扫描电化学显微镜测量Cr 3 + 诱导离子通道跨模拟生物膜的电子转移速率的研究

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摘要

To investigate the mechanism of Cr ion translocation across the cell membranes, the interaction between the Cr ion and the mimic biomembrane of solid supported lipid bilayer (s-BLM) has beeninvestigated quantitatively. The mimic biomembrane was prepared according to the self-assemble ofthe phosphatidylcholiner(PC)/cholesterol(Ch) membrane on Pt electrode. Using ferricyanide anionsspecies as a redox probe, cyclic voltammetric (CV), Alternating Current (A.C.) impedancespectroscopy (EIS), scanning electrochemical microscopy (SECM) and approach curves weremeasured. The apparent electron transfer rate constants between the surface of the electrode and redoxspecies was independently calculated from the approach curve, which was measured by SECM, to prove quantitatively the model of the biomimic membrane interacted with Cr in differentconcentration. The result showed that the apparent electron transfer rate constants increased as the -5 -1 - concentration of Cr attached to the surface of the s-BLM increased from 9.0010 cms to 1.0210 2 -1 -1 -1 cms while the concentration of Cr from 0 mgL to 780 mgL and two obvious platforms were-4 -1 -3 -1 observed at the constants of 9.310 cm and 7.6410 cm respectively. The mechanism was suggested that Cr ion interacted with the s-BLM and formed the ion-channels owing to the changesof the surface texture of the s-BLM, which resulted chromium ion translocation across mimicbiomembrane by Cr interaction with the Pt-BLM.
机译：为了研究Cr离子跨细胞膜转运的机理，已定量研究了Cr离子与固相支持脂质双层（s-BLM）的模拟生物膜之间的相互作用。根据磷脂酰胆碱（PC）/胆固醇（Ch）膜在铂电极上的自组装制备了模拟生物膜。使用铁氰化物阴离子物种作为氧化还原探针，测量了循环伏安（CV），交流电（A.C.）阻抗谱（EIS），扫描电化学显微镜（SECM）和接近曲线。电极表面和氧化还原物种之间的表观电子传递速率常数是根据SECM测量的接近曲线独立计算得出的，定量证明了仿生膜在不同浓度下与Cr相互作用的模型。结果表明，表观电子传递速率常数随着附着在s-BLM表面的Cr的-5 -1-浓度从9.0010 cms增加到1.0210 2 -1 -1 -1 -1 cms而增加。在9.301 cm和7.6410 cm的常数处分别观察到0 mgL至780 mgL和两个明显的平台为-4 -1 -3 -1。提示该机理是由于s-BLM表面织构的变化，Cr离子与s-BLM相互作用而形成离子通道，这是由于Cr与Pt-BLM相互作用而导致铬离子跨模拟生物膜的迁移。

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