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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Behaviors of Ceftazidime at Gr/GCE and its Interaction with DNA Studied by Fluorescence and CV Method
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Electrochemical Behaviors of Ceftazidime at Gr/GCE and its Interaction with DNA Studied by Fluorescence and CV Method

机译：头孢他啶在Gr / GCE上的电化学行为及其与DNA相互作用的荧光和CV研究

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摘要

The electrochemical behaviors of CFD (ceftazidime) at a graphene modified electrode (Gr/GCE) wereinvestigated by cyclic voltammetry. Compared with a bare glassy carbon electrode, the Gr/GCEexhibited a significantly enlarged irreversible oxidation peak due to the excellent electron transferfunction and catalytic effect of graphene. The peak currents were proportional to CFD concentration of0.25~10.0 μΜ and 10.0~75.0 μM, with the detection limit of 0.1 μM. Furthermore, the interactionbetween CFD and double stranded DNA was studied by electrochemical and fluorescence methods. Theresults showed that the peak current of CFD decreased remarkably and the fluorescence intensityquenched significantly with the increasing of DNA concentration, which indicated that the CFDmolecule intercalated into DNA to form a CFD-DNA complex. In addition, the number of electronstransferred in the electrochemical reaction was calculated based on the electrochemical results to assessthe possible interaction mechanisms.
机译：通过循环伏安法研究了CFD（头孢他啶）在石墨烯修饰电极（Gr / GCE）上的电化学行为。与裸露的玻璃碳电极相比，Gr / GCE表现出显着扩大的不可逆氧化峰，这是由于石墨烯具有出色的电子传递功能和催化作用。峰值电流与CFD浓度为0.25〜10.0μM和10.0〜75.0μM成比例，检测极限为0.1μM。此外，通过电化学和荧光方法研究了CFD与双链DNA之间的相互作用。结果表明，CFD的峰值电流随着DNA浓度的增加而显着下降，荧光强度明显减弱，这表明CFD分子嵌入DNA中形成了CFD-DNA复合物。此外，基于电化学结果计算了电化学反应中转移的电子数，以评估可能的相互作用机理。

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