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首页> 外文期刊>International Journal of Electrochemical Science >Pharmaceutical Electrochemistry: the Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes
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Pharmaceutical Electrochemistry: the Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes

机译：药物电化学：基于丝网印刷石墨烯电极的生物样品中扑热息痛的电化学氧化及其伏安传感

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摘要

We present a sensitive, fast and unmodified sensor for the electrochemical detection of paracetamol.The electrochemical behaviours of paracetamol on screen printed graphene electrodes wereinvestigated for the first time by cyclic voltammetry. The results showed that the screen printedgraphene electrodes revealed exceptional electrocatalytic activity to paracetamol. The response showedby this sensor was enhanced when it was compared to the bare screen printed electrodes.When Screen Printed Graphene Electrodes were compared to bare SPE, it was shown that the responsewith graphene was greater than without. This is due to its unique characteristics physical and chemical,- interactions and a strong adsorptive capability.In this manuscript, the effect of supporting electrolyte, pH and scan rate were also investigated.The oxidation peak current was linearly proportional to the concentration of paracetamol in the rangefrom 0.1 to 50 M with a limit of detection of 20nM based on (3-/slope), under the optimumconditions. The proposed method was successfully applied to paracetamol determination in inbiological samples such as human oral fluid.
机译：我们提供了一种灵敏，快速且未经修饰的传感器，用于对乙酰氨基酚的电化学检测。首次通过循环伏安法研究了对乙酰氨基酚在丝网印刷石墨烯电极上的电化学行为。结果表明，丝网印刷的石墨烯电极对扑热息痛具有优异的电催化活性。与裸丝网印刷电极相比，该传感器显示的响应得到了增强。当丝网印刷石墨烯电极与裸露SPE进行比较时，显示出石墨烯的响应大于无石墨烯的电极。这是由于其独特的物理和化学特性，相互作用和强大的吸附能力。在本文中，还研究了支持电解质，pH和扫描速率的影响。氧化峰电流与对乙酰氨基酚的浓度成线性比例。在最佳条件下，基于（3- /斜率）的检测范围为0.1至50 M，检测极限为20nM。所提出的方法已成功地用于生物样品（如人类口腔液）中扑热息痛的测定。

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