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首页> 外文期刊>International Journal of Electrochemical Science >The Effect of Cadmium Ions and Cadmium Nanoparticles on Chicken Embryos and Evaluation of Organ Accumulation
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The Effect of Cadmium Ions and Cadmium Nanoparticles on Chicken Embryos and Evaluation of Organ Accumulation

机译：镉离子和镉纳米颗粒对鸡胚的影响及器官积累的评价

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The presence of metals in the organism has both positive and negative influence on the functions of thebody, depending on the concentration. Cadmium is one of the metals that have irrefutable negativeeffect. It is highly toxic metal with long biological half-life causing damage of kidneys, bones and hascarcinogenic effect. The aim of this work was the study of the effect and distribution of the cadmiumin the body and its comparison with cadmium nanoparticles CdTe quantum dots (QDs). Modelth organism for these experiments was chicken embryo in 16 developmental day. The distribution ofcadmium was analyzed after the application of 500 L of cadmium solution (Cd ions) in concentration1 mg/mL or 4.5 mg/mL). This solution was applied through the small hole in the egg shell onto thechorioallantoic membrane. After 24 hours of the incubation (37.5 C, 45% rH) liver, kidney, brain andhearth were extracted. The concentration of cadmium was analyzed after the mineralization of thesamples by atomic absorption spectrometry and differential pulse voltammetry. The toxicity ofcadmium solution was significantly higher compared to the solution of QDs. Embryos exposed to thecadmium ions exhibited 100% mortality after 24 hours. On the contrary, the mortality of embryosexposed to QDs was 0%. The highest levels of cadmium were detected in the kidneys (125 g per g)and in the liver (107 g per g).
机译：金属中金属的存在，对人体的功能有正影响，也有负面影响，具体取决于浓度。镉是具有不可辩驳的负面影响的金属之一。它是高毒性金属，具有较长的生物半衰期，会导致肾脏，骨骼损坏并具有致癌作用。这项工作的目的是研究镉在体内的作用和分布，并将其与镉纳米粒子CdTe量子点（QDs）进行比较。这些实验的模型生物是发育第16天的鸡胚。应用浓度为1 mg / mL或4.5 mg / mL的500 L镉溶液（Cd离子）后，分析镉的分布。通过卵壳中的小孔将该溶液施加到绒毛膜尿囊膜上。温育24小时（37.5℃，45％rH）后，提取肝，肾，脑和壁炉。样品矿化后，通过原子吸收光谱法和差分脉冲伏安法分析镉的浓度。镉溶液的毒性比量子点溶液高得多。暴露于镉离子的胚胎在24小时后表现出100％的死亡率。相反，暴露于量子点的胚胎的死亡率为0％。在肾脏（每克125克）和肝脏（每克107克）中检测到最高的镉含量。

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