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首页> 外文期刊>International Journal of Electrochemical Science >Multi-walled Carbon Nanotube Modified Electrode for Sensitive Determination of an Anesthetic Drug: Tetracaine Hydrochloride
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Multi-walled Carbon Nanotube Modified Electrode for Sensitive Determination of an Anesthetic Drug: Tetracaine Hydrochloride

机译：用于麻醉药灵敏测定的多壁碳纳米管修饰电极：盐酸四卡因

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摘要

Carboxylated multi-walled carbon nanotubes (MWNTs) were directly cast on a glassy carbonelectrode (GCE) to fabricate a MWNT-modified GCE. The modified electrode exhibited goodelectrocatalytic activity to the electrochemical oxidation of tetracaine hydrochloride (TCH) withgreatly enhanced peak currents and negative shift of oxidation peak potential. The results showed thatthe electrochemical reaction of TCH was an irreversible, diffusion-controlled and two-electron coupledwith two-proton process. Effects of scan rate, pH of electrolyte solution, accumulation condition andthe cast volume of MWNTs suspension had been discussed and optimized. Under optimizedconditions, the amperometric current-time response on the MWNT-modified electrode was-7 -5 -1 proportional to the TCH concentration in the range of 1.010 -2.010 mol L with a detection limit-8 -1 (defined as 3Sb/m) of 3.610 mol L . The proposed method was successfully applied to thedetermination of tetracaine hydrochloride in commercial tablets. This simple, convenient, sensitive andinexpensive method could possibly be employed in quality control and routine determination of drugsin pharmaceutical formulations.
机译：将羧基化的多壁碳纳米管（MWNT）直接浇铸在玻璃碳电极（GCE）上，以制造MWNT改性的GCE。修饰电极对盐酸丁卡因（TCH）的电化学氧化表现出良好的电催化活性，峰值电流大大增加，氧化峰电位负移。结果表明，TCH的电化学反应是不可逆的，具有扩散控制和双电子加双质子过程。讨论并优化了扫描速率，电解质溶液的pH，堆积条件和MWNTs悬浮液的浇铸量的影响。在优化条件下，MWNT修饰电极上的电流电流-时间响应为-7 -5 -1，与TCH浓度成正比，范围为1.010 -2.010 mol L，检测极限为-8 -1（定义为3Sb / m ）3.610 mol L。该方法成功地用于商品片剂中盐酸丁卡因的测定。这种简单，方便，灵敏且廉价的方法可用于药物制剂中药物的质量控制和常规测定。

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