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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Sensor Using Glassy Carbon Electrode Modified with HPMáFP/Ppy/GCE Composite Film for Determination of Ofloxacin
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Electrochemical Sensor Using Glassy Carbon Electrode Modified with HPMáFP/Ppy/GCE Composite Film for Determination of Ofloxacin

机译：HPMáFP/ Ppy / GCE复合膜修饰玻碳电极测定氧氟沙星的电化学传感器

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In this work, an electrochemical sensor HPMP / Ppy /GCE (HPMaFP: 1-phenyl-3-methyl-4-(2- furoyl)-5-pyrazolone, Ppy: polypyrrole, GCE: glassy carbon electrode) was prepared for thedetermination of ofloxacin (OFL: (+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid). The electrochemical parameters ofofloxacin were investigatigated by cyclic voltammetry and differential pulse voltammetry. In pH=7.0phosphate buffer solution, one sensitive oxidation peak of OFL with Ep=0.88V is obtained on theelectrochemical sensor. The difference of peak potential(p) was 70mV lower than which on bareglassy carbon electrode, and the potential of ofloxacin moved negatively slightly which on Ppymodified electrode嶤ompared to the bare GCE and Ppy /GCE, the electrochemical sensor showed anexcellent electrocatalytic effect on the oxidation of ofloxacin and displayed a shift of the oxidationpotential in the negative direction with significant increase in the peak current. Under the optimumed- condition in voltammetric method, the concentration calibration range and detection limit are 210 6 -4 -8 ~110 mol/L and 6.510 mol/L for OFL. This developed method had been applied to the directdetermination of OFL in ophthalmic solution samples.
机译：在这项工作中，准备了电化学传感器HPMP/ Ppy / GCE（HPMaFP：1-苯基-3-甲基-4-（2-呋喃基）-5-吡唑啉酮，Ppy：聚吡咯，GCE：玻璃碳电极）氧氟沙星（OFL：（+-）-9-Fluoro-2,3-dihydro-3-methyl-10-（4-methyl-1-piperazinyl）-7- oxo-7H-pyrido（1,2,3）的测定-de）-1,4-苯并恶嗪-6-羧酸）。通过循环伏安法和差分脉冲伏安法研究了氧氟沙星的电化学参数。在pH = 7.0的磷酸盐缓冲溶液中，在电化学传感器上获得了一个Ep = 0.88V的OFL的敏感氧化峰。峰电位（p）的差值比裸玻璃碳电极低70mV，氧氟沙星的电位略有负向移动，这在Ppy修饰电极上比裸露的GCE和Ppy / GCE差，电化学传感器显示出对GCE和Ppy / GCE优异的电催化作用。氧氟沙星的氧化，并显示出负电位的氧化电位移动，峰值电流显着增加。在伏安法的最佳条件下，OFL的浓度校准范围和检出限为210 6 -4 -8〜110 mol / L和6.510 mol / L。该开发的方法已应用于眼药水样品中OFL的直接测定。

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