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首页> 外文期刊>International Journal of Electrochemical Science >Novel Polymeric Membrane and Coated Wire Electrodes for Determination of Alverine Citrate in Pharmaceutical Formulations and Biological Fluids
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Novel Polymeric Membrane and Coated Wire Electrodes for Determination of Alverine Citrate in Pharmaceutical Formulations and Biological Fluids

机译：用于测定药物制剂和生物液中柠檬酸柠檬酸的新型聚合物膜和包覆丝电极

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Selective and sensitive alverine electrodes have been fabricated by constructing a polymeric membrane(PME) and coated wire (CWE) electrodes. These are based on the ion-pair between phosphotungsticacid (PME1, CWE1) and phosphomolybdic acid (PME2, CWE2) in a poly (vinyl chloride) matrix,plasticized with DBP. The influence of membrane composition and pH on the potentiometricresponses of electrodes was investigated. The response characteristics of the membrane were comparedwith polymeric membrane electrode (PME) as well as with coated wire electrode (CWE). The-1 electrodes exhibit Nernstian slope of 59.10.4, 59.30.6, 59.21.1 and 59.51.1 mV decade with-6 -6 -6 -6 -1 limits of detection of 7.610 , 8.310 , 6.610 and 8.110 mol L alverine citrate for PME1,PME2, CWE1 and CWE2, respectively. Furthermore, the electrodes generated constant potentials in thepH range of 1.44-8.05 and 1.42-8.31 for PME1 and PME2, respectively. Selectivity coefficients foralverine citrate relative to numbers of potential interfering substances were investigated. Theelectrodes were highly selective for alverine over a large number of similar compounds. The proposedelectrodes displayed useful analytical characteristics for the determination of alverine citrate in bulkpowder, pharmaceutical formulation, and biological fluids (urine and plasma). The practical utility ofthe proposed electrodes has also been demonstrated by thier usage as indicator electrodes inpotentiometric titration of phosphotungstic acid with alverine cation solution.
机译：通过构建聚合物膜（PME）和包覆线（CWE）电极，可以制造选择性和灵敏的Alverine电极。这些基于在用DBP增塑的聚（氯乙烯）基质中的磷钨酸（PME1，CWE1）和磷钼酸（PME2，CWE2）之间的离子对。研究了膜组成和pH对电极电位响应的影响。将该膜的响应特性与聚合物膜电极（PME）以及涂覆线电极（CWE）进行了比较。 -1电极的Nernstian斜率为59.10.4、59.30.6、59.21.1和59.51.1 mV十倍频程，具有6 -6 -6 -6 -1 -1的检出限，分别为7.610、8.310、6.610和8.110 mol L ver柠檬酸盐分别用于PME1，PME2，CWE1和CWE2。此外，对于PME1和PME2，电极分别在1.44-8.05和1.42-8.31的pH范围内产生恒定电势。研究了柠檬酸金丝桃相对于潜在干扰物质数量的选择性系数。电极对大量类似化合物具有较高的选择性。拟议的电极显示出用于测定散装粉末，药物制剂和生物体液（尿液和血浆）中柠檬酸柠檬酸的有用分析特性。所提出的电极的实际用途还已经通过将它们用作指示电极，用金银花阳离子溶液电位滴定磷钨酸来证明。

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