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首页> 外文期刊>International Journal of Electrochemistry >A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography
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A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

机译：单扫描极谱法测定药物中苯佐卡因和普鲁卡因的新方法

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摘要

A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed. Experimental conditions affecting quantitative yield of benzocaine and procaine oxidation products such as рH, oxidation time, reagents’ concentration, and temperature are explored. It is shown that the reduction current changes in a linear fashion (R=0.999) with increasing concentration of anesthetics over a concentration range of 1·10−6 - 5·10−5 mol L−1. The calculated limits of detection (LOD) for benzocaine and procaine are found to be 5.6·10−6 and 6·10−6 mol L−1, respectively. In the present study, quantitative polarographic determination of benzocaine in Farisil tablets and “Septolete Plus” lozenges and procaine in solution for injections is performed. The results of the analysis are in good agreement with the product specifications described in the quality certificates. The possibility of quantitative determination of benzocaine and procaine in pharmaceuticals is confirmed.
机译：建立了一种新的极谱法测定苯佐卡因和普鲁卡因，方法是用过氧一硫酸钾对它们的化学氧化产物进行极谱法还原。探索了影响苯并卡因和普鲁卡因氧化产物定量收率的实验条件，例如рH，氧化时间，试剂浓度和温度。结果表明，在1×10-6-5×10-5 mol L-1的浓度范围内，随着麻醉剂浓度的增加，还原电流呈线性变化（R = 0.999）。计算得出的苯佐卡因和普鲁卡因的检出限（LOD）分别为5.6·10-6和6·10-6 mol L-1。在本研究中，对Farisil片剂中的苯佐卡因和注射溶液中的“ Septolete Plus”锭剂和普鲁卡因进行了定量极谱法测定。分析结果与质量证书中所述的产品规格非常吻合。证实了定量测定药物中苯佐卡因和普鲁卡因的可能性。

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