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首页> 外文期刊>International Journal of Electrochemistry >Carbon Nanoelectrodes for the Electrochemical Detection of Neurotransmitters
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Carbon Nanoelectrodes for the Electrochemical Detection of Neurotransmitters

机译:用于神经递质电化学检测的碳纳米电极

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Carbon-based electrodes have been developed for the detection of neurotransmitters over the past 30 years using voltammetry and amperometry. The traditional electrode for neurotransmitter detection is the carbon fiber microelectrode (CFME). The carbon-based electrode is suitable for in vivo neurotransmitter detection due to the fact that it is biocompatible and relatively small in surface area. The advent of nanoscale electrodes is in high demand due to smaller surface areas required to target specific brain regions that are also minimally invasive and cause relatively low tissue damage when implanted into living organisms. Carbon nanotubes (CNTs), carbon nanofibers, carbon nanospikes, and carbon nanopetals among others have all been utilized for this purpose. Novel electrode materials have also required novel insulations such as glass, epoxy, and polyimide coated fused silica capillaries for their construction and usage. Recent research developments have yielded a wide array of carbon nanoelectrodes with superior properties and performances in comparison to traditional electrode materials. These electrodes have thoroughly enhanced neurotransmitter detection allowing for the sensing of biological compounds at lower limits of detection, fast temporal resolution, and without surface fouling. This will allow for greater understanding of several neurological disease states based on the detection of neurotransmitters.
机译:在过去的30年中,已经开发出了基于碳的电极,用于使用伏安法和安培法检测神经递质。用于神经递质检测的传统电极是碳纤维微电极(CFME)。碳基电极具有生物相容性且表面积相对较小,因此适用于体内神经递质的检测。由于靶向特定大脑区域所需的表面积较小,因此纳米级电极的出现需求很高,当植入生物体时,这种特定区域也具有最小的侵入性,并且对组织的损害较小。碳纳米管(CNT),碳纳米纤维,碳纳米钉和碳纳米花瓣等已全部用于此目的。新型电极材料还需要新型绝缘材料,例如玻璃,环氧树脂和聚酰亚胺涂层的熔融石英毛细管,以用于其构造和使用。与传统电极材料相比,最近的研究开发已经产生了一系列具有优异性能和性能的碳纳米电极。这些电极具有完全增强的神经递质检测功能,可以在较低的检测限,快速的时间分辨力且没有表面污染的情况下感应生物化合物。基于神经递质的检测,这将使人们更好地了解几种神经系统疾病状态。

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