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首页> 外文期刊>International Journal of Experimental Diabetes Research: Experimental Diabesity Research >Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus
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Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus

机译：内质网处于自噬，炎症和细胞凋亡信号通路的十字路口，并参与糖尿病的发病机理

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摘要

Diabetes mellitus (DM) is a chronic metabolic disease, and its incidence is growing worldwide. The endoplasmic reticulum (ER) is a central component of cellular functions and is involved in protein folding and trafficking, lipid synthesis, and maintenance of calcium homeostasis. The ER is also a sensor of both intra- and extracellular stress and thus participates in monitoring and maintaining cellular homeostasis. Therefore, the ER is one site of interaction between environmental signals and a cell’s biological function. The ER is tightly linked to autophagy, inflammation, and apoptosis, and recent evidence suggests that these processes are related to the pathogenesis of DM and its complications. Thus, the ER has been considered an intersection integrating multiple stress responses and playing an important role in metabolism-related diseases including DM. Here, we review the relationship between the ER and autophagy, inflammation, and apoptosis in DM to better understand the molecular mechanisms of this disease.
机译：糖尿病（DM）是一种慢性代谢性疾病，在世界范围内其发病率正在增长。内质网（ER）是细胞功能的核心组成部分，参与蛋白质折叠和运输，脂质合成以及钙稳态的维持。 ER还是细胞内和细胞外应激的传感器，因此参与监测和维持细胞稳态。因此，ER是环境信号与细胞生物学功能之间相互作用的一个场所。 ER与自噬，炎症和凋亡密切相关，最近的证据表明这些过程与DM的发病机制及其并发症有关。因此，ER被认为是整合了多种应激反应并在包括DM在内的代谢相关疾病中起重要作用的交叉点。在这里，我们审查内质网与DM中自噬，炎症和细胞凋亡之间的关系，以更好地了解这种疾病的分子机制。

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