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首页> 外文期刊>International Journal of Environmental Research and Public Health >Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection
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Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection

机译：HLA-DM多态性对慢性丙型肝炎病毒1型感染患者对干扰素/利巴韦林的治疗反应

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Background: HLA-DM gene, which is related to antigen processing and presentation and located in the non-classical class-II region of human leukocyte antigen (HLA) region, may play a crucial role in chronic hepatitis C virus (HCV) infection treatment outcomes. The study was conducted to evaluate the role of the variant of several single nucleotide polymorphisms (SNPs) in HLA-DM gene in HCV treatment outcomes. Methods: We genotyped four SNPs from the candidate genes ( HLA-DMA and DMB ) in 336 patients who were treated with pegylated interferon-alpha and ribavirin (PEG IFN-α/RBV). Multivariate analysis of factors predicting sustained virological response (SVR) was conducted. Results: HLA-DMA rs1063478 and DMB rs23544 were independent factors of HCV treatment outcomes in Chinese Han population. Individuals who carried favorable genotypes of rs1063478TT and rs23544GG were more likely to achieve SVR {Dominant model: odds ratio (OR) = 2.05, 95% confidence interval (CI) = 1.24–3.41; OR = 2.04, 95% CI =1.23–3.35, respectively}. Rs23544, rs1063478, baseline glucose, baseline platelet and T4 level were independent predictors of SVR. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.740. Conclusions: The genetic variation of rs1063478 and rs23544 are associated with the treatment outcomes in the Chinese Han population.
机译：背景：HLA-DM基因与抗原的加工和呈递有关，位于人类白细胞抗原（HLA）区域的非经典II类区域，可能在慢性丙型肝炎病毒（HCV）感染的治疗中起关键作用结果。进行该研究以评估HLA-DM基因中几种单核苷酸多态性（SNP）变异体在HCV治疗结果中的作用。方法：我们对来自336名接受聚乙二醇干扰素-α和利巴韦林（PEGIFN-α/ RBV）治疗的患者的候选基因（HLA-DMA和DMB）中的四个SNP进行了基因分型。进行了预测持续病毒学应答（SVR）的因素的多变量分析。结果：HLA-DMA rs1063478和DMB rs23544是中国汉族人群HCV治疗结果的独立因素。携带有利基因型rs1063478TT和rs23544GG的个体更可能实现SVR {优势模型：优势比（OR）= 2.05，95％置信区间（CI）= 1.24–3.41; OR = 2.04，95％CI分别为1.23–3.35}。 Rs23544，rs1063478，基线血糖，基线血小板和T4水平是SVR的独立预测因子。接收器工作特性（ROC）曲线（AUC）下的面积为0.740。结论：rs1063478和rs23544的遗传变异与中国汉族人群的治疗结果相关。

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