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首页> 外文期刊>International Journal of Environmental Research and Public Health >A Preliminary Assessment of the Role of Ambient Nitric Oxide Exposure in Hospitalization with Respiratory Syncytial Virus Bronchiolitis
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A Preliminary Assessment of the Role of Ambient Nitric Oxide Exposure in Hospitalization with Respiratory Syncytial Virus Bronchiolitis

机译：暴露于环境中的一氧化氮在呼吸道合胞病毒细支气管炎住院治疗中的作用初步评估

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摘要

Some in vitro studies have indicated a possible link between respiratory syncytial virus (RSV) infection and exposure to Nitric Oxide (NO). However, these studies used much higher NO concentrations than normally found in the ambient environment. This preliminary study explored whether an association was present with short-term exposure to NO in the environment. RSV-related admission data between November 2011 and February 2012 were obtained from Sheffield Children’s Hospital. The dates of admission were linked to contemporaneous ambient NO derived from sentinel air monitors. The case-crossover design was used to study the relationship between daily RSV admissions and NO, controlling for temperature and relative humidity. We found little evidence of association between daily RSV admission rates and exposure to ambient NO at different lags or average exposure across several lags. The findings should, however, be viewed with caution due to the low number of events observed during the time frame. It is possible that the apparent lack of association may be accounted for by the timing of the seasonal RSV epidemic in relation to peaks in NO concentrations. A larger study incorporating a wider range of RSV and NO peaks would determine whether said peaks enhanced the number of RSV hospitalizations in children.
机译：一些体外研究表明，呼吸道合胞病毒（RSV）感染与一氧化氮（NO）暴露之间可能存在联系。但是，这些研究使用的NO浓度比周围环境中的正常浓度高得多。这项初步研究探讨了环境中是否存在短期暴露于NO的关联。从谢菲尔德儿童医院获得2011年11月至2012年2月期间与RSV相关的入院数据。入院日期与前哨空气监测仪得出的同期环境NO相关。病例交叉设计用于研究每日RSV摄入量与NO之间的关系，并控制温度和相对湿度。我们发现很少有证据表明每日RSV入场率与不同滞后或环境中的平均NO暴露之间存在关联。但是，由于在该时间段内观察到的事件数量很少，因此应谨慎对待这些发现。可能由于季节性RSV流行与NO浓度峰值有关的时间安排而导致明显缺乏关联。一项包含更大范围的RSV和NO峰值的较大研究将确定所述峰值是否增加了儿童的RSV住院人数。

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