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首页> 外文期刊>International Journal of Environmental Research and Public Health >Distribution of High-Sensitivity C-Reactive Protein and Its Relationship with Other Cardiovascular Risk Factors in the Middle-Aged Chinese Population
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Distribution of High-Sensitivity C-Reactive Protein and Its Relationship with Other Cardiovascular Risk Factors in the Middle-Aged Chinese Population

机译：中国中老年人高敏C反应蛋白的分布及其与其他心血管危险因素的关系

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Background: An increased concentration of high-sensitivity C-reactive protein (hs-CRP) indicates risk for cardiovascular disease (CVD). Because the available data is limited, a cross-sectional survey was conducted in 2009–2010 to describe hs-CRP distribution and its relationship with established CVD risk factors. Methods: A population-based sample of adults aged 35 to 64 years ( n = 14,046) was taken from 12 research populations across China. Demographic and clinical characteristics were recorded, and hs-CRP measured. Pearson’s and Kendall’s tau-b correlation coefficient, and multiple regression analyses were used to test the relationship between hs-CRP and other CVD risk factors. Results: For 8389 (4412 females) eligible participants, hs-CRP was 1.89 ± 4.37 mg/L (median (25th, 75th): 0.80 (0.40, 1.80)), and increased with age, BP, glucose, and BMI ( p < 0.05), males had significantly higher hs-CRP than females (2.07 (4.89) vs. 1.73 (3.83), p < 0.001). About 24.3% had the hs-CRP concentrations more than the top quartile (25.8% in males, 22.9% in females), 12.3% (13.3% in males, 11.5% in females) >3 mg/L. There was a significant positive correlation of quartiles of hs-CRP concentrations with age, SBP, DBP, glucose level, BMI, LDL-C/HDL-C ratio, and LDL-C/total cholesterol ratio ( p < 0.001). The elevated hs-CRP (>1.80 mg/L) related positively with age, LDL-C, BP, glucose, BMI, and living north and negatively with HDL-C/TC, LDL-C/TC, TC independently ( p < 0.05). For subjects with coexisting hypertension, diabetes, high cholesterol, and obesity, about 63.0% were in the top quartile of hs-CRP concentrations. Conclusions: Hs-CRP was associated with most of the known CVD risk factors. Measurement of hs-CRP may provide a more comprehensive view of the patient’s overall risk profile in the Chinese population.
机译：背景：高敏C反应蛋白（hs-CRP）浓度升高表明存在心血管疾病（CVD）的风险。由于可用数据有限，因此在2009–2010年进行了横断面调查，以描述hs-CRP分布及其与已确定的CVD危险因素的关系。方法：从中国12个研究人群中抽取35到64岁（n = 14046）的成年人作为研究对象。记录人口和临床特征，并测量hs-CRP。皮尔森（Pearson）和肯德尔（Kendall）的tau-b相关系数以及多重回归分析用于检验hs-CRP与其他CVD危险因素之间的关系。结果：对于8389名（4412名女性）合格参与者，hs-CRP为1.89±4.37 mg / L（中位数（25、75）：0.80（0.40、1.80）），并且随着年龄，血压，血糖和BMI的升高而增加（p <0.05），男性的hs-CRP显着高于女性（2.07（4.89）对1.73（3.83），p <0.001）。 > 3 mg / L的hs-CRP浓度高于最高四分位数（男性为25.8％，女性为22.9％），12.3％（男性为13.3％，女性为11.5％）。 hs-CRP浓度的四分位数与年龄，SBP，DBP，葡萄糖水平，BMI，LDL-C / HDL-C比和LDL-C /总胆固醇比呈显着正相关（p <0.001）。 hs-CRP（> 1.80 mg / L）升高与年龄，LDL-C，BP，葡萄糖，BMI和北部地区呈正相关，与HDL-C / TC，LDL-C / TC，TC呈负相关（p < 0.05）。对于高血压，糖尿病，高胆固醇和肥胖症并存的受试者，hs-CRP浓度的前四分之一约为63.0％。结论：Hs-CRP与大多数已知的CVD危险因素有关。对hs-CRP的测量可能会更全面地了解中国人群中患者的总体风险状况。

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