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首页> 外文期刊>International Journal of Environmental Research and Public Health >Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma
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Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

机译：啤酒及其非酒精性化合物：在胰腺外分泌，酒精性胰腺炎和胰腺癌中的作用。

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: In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. Some non-alcoholic compounds of beer, such as quercetin, resveratrol, ellagic acid or catechins, have been shown to be protective against experimentally induced pancreatitis by inhibiting pancreatic secretion, stellate cell activation or by reducing oxidative stress. Quercetin, ellagic acid and resveratrol also show anti-carcinogenic potential in vitro and in vivo. However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated.
机译：：在本文中，我们概述了有关酒精饮料（尤其是啤酒）的非酒精成分对胰腺分泌的影响及其在酒精性胰腺炎和胰腺癌中的可能作用的最新数据。数据表明，啤酒的非酒精成分至少部分地通过对胰腺腺泡细胞的直接作用来刺激人和大鼠的胰腺酶分泌。啤酒中的一些非酒精性化合物，例如槲皮素，白藜芦醇，鞣花酸或儿茶素，已被证明可通过抑制胰腺分泌，星状细胞活化或减轻氧化应激来抵抗实验性胰腺炎。槲皮素，鞣花酸和白藜芦醇在体外和体内也显示出抗癌潜力。但是，啤酒含有更多的非酒精成分。它们与啤酒诱导的胰腺细胞功能改变导致人类胰腺炎和胰腺癌的相关性需要进一步评估。

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