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首页> 外文期刊>International Journal of Environmental Research and Public Health >Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-brain Barrier: Expanding the Awareness of Smoking Toxicity in an Underappreciated Area
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Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-brain Barrier: Expanding the Awareness of Smoking Toxicity in an Underappreciated Area

机译：香烟烟雾暴露对脑血管系统的病理生理影响（重点是血脑屏障）：在人们认识不到的地区扩大了吸烟毒性的意识

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摘要

Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, significantly increasing the risk for ischemic manifestations such as acute coronary syndrome and stroke. Despite the strong evidence for an association between smoking and vascular impairment, the impact of TS exposure on the blood-brain barrier (BBB) has only been marginally addressed. This is a major problem given that the BBB is crucial in the maintenance of brain homeostasis. Recent data have also shown that chronic smokers have a higher incidence of small vessel ischemic disease (SVID), a pathological condition characterized by leaky brain microvessels and loss of BBB integrity. In the brain TS increases the risk of silent cerebral infarction (SCI) and stroke owing to the pro-coagulant and atherogenic effects of smoking. In this article we provide a detailed review and analysis of current knowledge of the pathophysiology of tobacco smoke toxicity at the cerebrovascular levels. We also discuss the potential toxicity of recently marketed “potential-reduced exposure products”.
机译：最近的证据表明，主动和被动吸烟与正常的内皮生理功能障碍呈剂量依赖性。烟草烟雾（TS）可能使个体易患动脉粥样硬化和血栓形成问题，从而大大增加了缺血性表现如急性冠状动脉综合征和中风的风险。尽管有强有力的证据表明吸烟与血管损伤之间存在关联，但TS暴露对血脑屏障（BBB）的影响仅得到了轻微解决。鉴于BBB在维持脑稳态方面至关重要，因此这是一个主要问题。最近的数据还显示，慢性吸烟者发生小血管缺血性疾病（SVID）的几率更高，这是一种以脑微血管渗漏和BBB完整性丧失为特征的病理状况。在大脑中，TS会由于吸烟的促凝作用和动脉粥样硬化作用而增加无症状性脑梗塞（SCI）和中风的风险。在本文中，我们对脑血管水平上烟草烟雾毒性的病理生理学的最新知识进行了详细的回顾和分析。我们还讨论了最近上市的“潜在减少接触产品”的潜在毒性。

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