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首页> 外文期刊>International Journal of Environmental Research and Public Health >Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats
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Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats

机译：184天重复口服给药对大鼠无烟烟草提取物的毒性

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The use of smokeless tobacco (ST) is growing rapidly and globally. The consumption of ST is associated with an increased risk for developing chronic diseases, such as diabetes, hypercholesterolemia, and myocardial infarction, and has led to many public health problems. It is very important to access the toxicity of ST. This experiment presents data from 184-day toxicology studies in Sprague-Dawley (SD) rats designed to characterize the chronic effects of a smokeless tobacco extract (STE). The control group and treatment groups were matched for a range of nicotine levels. Animals were given STE by oral gavage with doses of 3.75 (low-dose), 7.50 (mid-dose) and 15.00 (high-dose) mg·nicotine/kg body weight/day for 184 days, followed by 30 days for recovery. Variables evaluated included body weights, feed consumption, clinical observations, clinical and anatomic pathology (including organ weights), and histopathology. Decreased body weights and organ weights (heart, liver and kidney) were found in animals in the mid-dose and high-dose groups. STE also showed moderate and reversible toxicity in esophagus, stomach, liver, kidney and lung.
机译：无烟烟草（ST）的使用正在全球范围内快速增长。 ST的摄入与患慢性疾病（如糖尿病，高胆固醇血症和心肌梗塞）的风险增加有关，并已导致许多公共卫生问题。获得ST的毒性非常重要。该实验提供了来自Sprague-Dawley（SD）大鼠的184天毒理学研究数据，这些数据旨在表征无烟烟草提取物（STE）的慢性作用。对照组和治疗组的烟碱水平相匹配。通过口服强饲法给动物STE，分别给予3.75（低剂量），7.50（中等剂量）和15.00（高剂量）mg·烟碱/ kg体重/天的剂量，持续184天，然后恢复30天。评估的变量包括体重，饲料消耗，临床观察，临床和解剖病理学（包括器官重量）以及组织病理学。在中剂量和高剂量组的动物中发现体重和器官重量（心脏，肝脏和肾脏）减少。 STE在食道，胃，肝，肾和肺中也显示出中度和可逆毒性。

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