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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population
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The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population

机译：朝鲜族人群饮酒与β细胞功能和胰岛素敏感性之间的关系

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This cross-sectional study was performed to examine the association between alcohol consumption and insulin secretion and sensitivity using the Korean Genome and Epidemiology Study. Alcohol consumption levels were categorized into four groups: (i) abstainers, (ii) low (<5 g/day), (iii) intermediate (<30 g/day), and (iv) high (≥30 g/day) alcohol consumption. β-cell function and insulin sensitivity were estimated using the insulinogenic index (IGI 60 ), and Matsuda insulin sensitivity index (ISI), respectively. IGI 60 and ISI were dichotomized into high and low groups using median cut-off values and four groups were defined (G-I: high IGI 60 /high ISI; G-II: high IGI 60 /low ISI; G-III: low IGI 60 /high ISI; and G-IV: low IGI 60 /low ISI). Men consumed 26.5 g alcohol per day on average, whereas women only consumed 5.7 g/day, so women were excluded from subsequent analyses due to their low drinking levels. Alcohol consumption was positively associated with high-density lipoprotein (HDL) cholesterol, aspartate aminotransferase (AST), and triglycerides (TG) in men, but was negatively associated with IGI 60 ( p < 0.05). TG levels were only increased in individuals with decreased insulin sensitivity (G-II) or decreased β-cell function (G-III) with high alcohol consumption. In addition, alcohol consumption increased HDL cholesterol in the four groups ( p < 0.001). In subjects with decreased insulin sensitivity (G-II), intermediate and high alcohol consumption increased the risk of high cholesterol and TG. In individuals with decreased β-cell function (G-III), alcohol consumption increased the risk of high TG and high AST levels. High alcohol consumption was significantly associated with reduced insulin secretion. In addition, alcohol consumption was related to some metabolic risk factors depending on insulin secretion or sensitivity.
机译：使用韩国基因组和流行病学研究进行了这项横断面研究，以研究饮酒与胰岛素分泌和敏感性之间的关系。酒精消费量分为四类：（i）戒酒者，（ii）低（<5 g /天），（iii）中度（<30 g /天），和（iv）高（≥30g /天）酒精消耗。分别使用致胰岛素指数（IGI 60）和松田胰岛素敏感性指数（ISI）估算β细胞功能和胰岛素敏感性。使用中位数截止值将IGI 60和ISI分为高组和低组，并定义了四组（GI：高IGI 60 /高ISI; G-II：高IGI 60 /低ISI; G-III：低IGI 60 /高ISI;以及G-IV：低IGI 60 /低ISI）。男性平均每天喝26.5克酒精，而女性每天仅喝5.7克，因此由于其低饮酒水平，女性被排除在后续分析之外。男性饮酒与高密度脂蛋白（HDL）胆固醇，天冬氨酸转氨酶（AST）和甘油三酸酯（TG）呈正相关，但与IGI 60呈负相关（p <0.05）。 TG水平仅在胰岛素敏感性降低（G-II）或β细胞功能降低（G-III）且饮酒量较高的个体中升高。此外，饮酒会增加四组的HDL胆固醇（p <0.001）。在胰岛素敏感性降低（G-II）的受试者中，中度和高度饮酒会增加高胆固醇和高TG的风险。在β-细胞功能下降（G-III）的个体中，饮酒会增加高TG和高AST水平的风险。高饮酒与胰岛素分泌减少显着相关。此外，饮酒与某些代谢危险因素有关，这取决于胰岛素的分泌或敏感性。

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