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首页> 外文期刊>International Journal of Environmental Research and Public Health >Cytokines and Adhesion Molecules Expression in the Brain in Human Cerebral Malaria
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Cytokines and Adhesion Molecules Expression in the Brain in Human Cerebral Malaria

机译：人脑疟疾脑中的细胞因子和粘附分子表达

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Although the role of systemic proinflammatory cytokines, IL-1β and TNF-α, and their up-regulation of adhesion molecules, ICAM-1, VCAM-1 and E-Selectin, in the pathogenesis of cerebral malaria (CM) is well established, the role of local cytokine release remain unclear. Immunohistochemistry (IHC) was used to compare the expression of ICAM-1, VCAM-1, E-Selectin, IL-1β, TNF-α and TGF- β at light microscopic level in cerebral, cerebellar and brainstem postmortem cryostat sections from 10 CM, 5 severe malarial anemia (SMA), 1 purulent bacterial meningitis (PBM), 2 non-central nervous system infections (NCNSI) and 3 non-infections (NI) deaths in Ghanaian children. Fatal malaria and Salmonella sepsis showed significantly higher vascular expression of all 3 adhesion molecules, with highly significant co-localization with sequestration in the malaria cases. However, there was negligible difference between CM and SMA. TGF-β showed intravascular and perivascular distribution in all cases, but expression was most intense in the PBM case and CM group. TNF-α and IL-1β showed prominent brain parenchymal staining, in addition to intravascular and perivascular staining, in only the PBM case and CM group. The maximal expression of all 6 antigens studied was in the cerebellar sections of the malaria cases. Endothelial activation is a feature of fatal malaria and Salmonella sepsis, with adhesion molecule expression being highly correlated with sequestration. IL-1β and TNF-α are upregulated in only cases with neurodegenerative lesions, whilst TGF-β is present in all cases. Both cytokines and adhesion molecules were maximally upregulated in the cerebellar sections of the malaria cases.
机译：尽管系统性促炎细胞因子IL-1β和TNF-α以及它们的黏附分子ICAM-1，VCAM-1和E-选择素在脑疟疾（CM）发病机制中的作用已被很好地确定，局部细胞因子释放的作用尚不清楚。使用免疫组织化学（IHC）比较了从10 CM处的脑，小脑和脑干死后低温恒温切片中ICAM-1，VCAM-1，E-选择素，IL-1β，TNF-α和TGF-β在光学显微镜下的表达。加纳儿童中5例严重的疟疾贫血（SMA），1例化脓性细菌性脑膜炎（PBM），2例非中枢神经系统感染（NCNSI）和3例非感染（NI）死亡。致命的疟疾和沙门氏菌败血症显示出所有3种粘附分子的血管表达均显着升高，在疟疾病例中，与螯合具有高度显着的共定位。但是，CM和SMA之间的差异可忽略不计。 TGF-β在所有情况下均显示血管内和血管周围分布，但在PBM和CM组中表达最强烈。仅在PBM病例和CM组中，TNF-α和IL-1β除血管内和血管周染色外，还表现出明显的脑实质染色。研究的所有6种抗原的最大表达是在疟疾病例的小脑切片中。内皮激活是致命性疟疾和沙门氏菌败血症的特征，其粘附分子的表达与螯合高度相关。 IL-1β和TNF-α仅在神经退行性病变的情况下上调，而TGF-β在所有情况下均存在。在疟疾病例的小脑部分，细胞因子和粘附分子均被最大上调。

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