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首页> 外文期刊>International Journal of Environmental Research and Public Health >Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications
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Vitamin D Status of Clinical Practice Populations at Higher Latitudes: Analysis and Applications

机译：较高纬度地区临床实践人群的维生素D状况：分析和应用

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Background:Inadequate levels of vitamin D (VTD) throughout the life cycle from the fetal stage to adulthood have been correlated with elevated risk for assorted health afflictions. The purpose of this study was to ascertain VTD status and associated determinants in three clinical practice populations living in Edmonton, Alberta, Canada - a locale with latitude of 53°30’N, where sun exposure from October through March is often inadequate to generate sufficient vitamin D.Methods: To determine VTD status, 1,433 patients from three independent medical offices in Edmonton had levels drawn for 25(OH)D as part of their medical assessment between Jun 2001 and Mar 2007. The relationship between demographic data and lifestyle parameters with VTD status was explored. 25(OH)D levels were categorized as follows: (1) Deficient: 40 nmol/L; (2) Insufficient (moderate to mild): 40 to 80 nmol/L; and (3) Adequate: 80–250 nmol/L. Any cases 25 nmol/L were subcategorized as severely deficient for purposes of further analysis.Results: 240 (16.75% of the total sample) of 1,433 patients were found to be VTD ‘deficient’ of which 48 (3.35% of the overall sample) had levels consistent with severe deficiency. 738 (51.5% of the overall sample) had ‘insufficiency’ (moderate to mild) while only 31.75% had ‘adequate’ 25(OH)D levels. The overall mean for 25(OH) D was 68.3 with SD=28.95. VTD status was significantly linked with demographic and lifestyle parameters including skin tone, fish consumption, milk intake, sun exposure, tanning bed use and nutritional supplementation.Conclusion: A high prevalence of hypovitaminosis-D was found in three clinical practice populations living in Edmonton. In view of the potential health sequelae associated with widespread VTD inadequacy, strategies to facilitate translation of emerging epidemiological information into clinical intervention need to be considered in order to address this public health issue. A suggested VTD supplemental intake level is presented for consideration.
机译：背景：从胎儿期到成年期的整个生命周期中维生素D（VTD）的含量不足均与各种健康疾病的风险增加有关。这项研究的目的是确定居住在加拿大艾伯塔省埃德蒙顿市（纬度为53°30'N的三个临床实践人群）中VTD的状况及其相关的决定因素，那里从10月到3月的日照通常不足以产生足够的热量。维生素D。方法：为确定VTD的状态，在2001年6月至2007年3月之间，埃德蒙顿三个独立医疗机构的1,433名患者抽取了25（OH）D水平作为其医学评估的一部分。探索了VTD状态。 25（OH）D水平分类如下：（1）不足：<40 nmol / L; （2）不足（中度至中度）：40至<80 nmol / L; （3）足够：80–250 nmol / L。任何<25 nmol / L的病例都被归类为严重缺乏症，以作进一步分析。结果：发现1,433名患者中有240名（占总样本数的16.75％）是VTD'缺乏'的，其中48名（占总样本数的3.35％） ）的水平符合严重缺乏症。 738名（占总样本的51.5％）“不足”（中度至轻度），而只有31.75％的“ 25”（OH）D足够。 25（OH）D的总体平均值为68.3，SD = 28.95。 VTD状态与人口统计学和生活方式参数显着相关，包括肤色，鱼的摄入量，牛奶摄入量，日光照射，晒黑床的使用和营养补充。考虑到与广泛的VTD不足相关的潜在健康后遗症，为了解决这个公共卫生问题，需要考虑将新兴流行病学信息转化为临床干预措施的策略。建议的VTD补充摄入量供考虑。

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