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首页> 外文期刊>International Journal of Environmental Research and Public Health >Comments on Scheffler et al. Cytotoxic Evaluation of E-Liquid Aerosol using Different Lung Derived Cell Models. Int. J. Environ. Res. Public Health, 2015, 12, 12466-12474
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Comments on Scheffler et al. Cytotoxic Evaluation of E-Liquid Aerosol using Different Lung Derived Cell Models. Int. J. Environ. Res. Public Health, 2015, 12, 12466-12474

机译:Scheffler等人的评论。使用不同的肺衍生细胞模型对E-液体气溶胶的细胞毒性评估。诠释J.环境。 Res。公共卫生,2015,12,12466-12474

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摘要

There is merit in considering a simple toxicological screening method that evaluates the total cytotoxic potential of e-liquids or electronic cigarettes (ECs) aerosol emissions in one single testing. However, there is growing confusion, with several researchers endorsing their personal solution to the problem. Here, we discuss as an example the recent paper by Scheffler and colleagues, in which the authors suggest that more relevant and well differentiated cell lines from human airways could be the most suitable candidates for toxicological evaluation of ECs aerosol emissions. We advance recommendations for validated protocols and advocate for an international coordinated effort aimed at establishing consensus on methodology.
机译:考虑一下一种简单的毒理学筛查方法的优点,该方法可以在一次测试中评估电子液体或电子香烟(ECs)气溶胶排放物的总细胞毒性潜力。但是,越来越多的困惑使一些研究人员认可他们对问题的个人解决方案。在这里,我们以Scheffler及其同事最近的论文为例进行讨论,其中作者认为来自人类呼吸道的更相关和分化程度更高的细胞系可能是最合适的ECs气溶胶排放物毒理学评估候选者。我们提出有关经过验证的方案的建议,并倡导进行国际协调,以期就方法论达成共识。

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