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首页> 外文期刊>International Journal of Environmental Research and Public Health >Development of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples
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Development of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples

机译：新型微萃取纤维与在线样品堆叠毛细管电泳紫外检测结合用于实际水样品中酸性药物的测定

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A new analytical method coupling a (off-line) solid-phase microextraction with an on-line capillary electrophoresis (CE) sample enrichment technique was developed for the analysis of ketoprofen, naproxen and clofibric acid from water samples, which are known as contaminants of emerging concern in aquatic environments. New solid-phase microextraction fibers based on physical coupling of chromatographic supports onto epoxy glue coated needle were studied for the off-line preconcentration of these micropollutants. Identification and quantification of such acidic drugs were done by capillary zone electrophoresis (CZE) using ultraviolet diode array detection (DAD). Further enhancement of concentration sensitivity detection was achieved by on-line CE “acetonitrile stacking” preconcentration technique. Among the eight chromatographic supports investigated, Porapak Q sorbent showed higher extraction and preconcentration capacities. The screening of parameters that influence the microextraction process was carried out using a two-level fractional factorial. Optimization of the most relevant parameters was then done through a surface response three-factor Box-Behnken design. The limits of detection and limits of quantification for the three drugs ranged between 0.96 and 1.27 μg?L ?1 and 2.91 and 3.86 μg?L ?1 , respectively. Recovery yields of approximately 95 to 104% were measured. The developed method is simple, precise, accurate, and allows quantification of residues of these micropollutants in Genil River water samples using inexpensive fibers.
机译：开发了一种新的分析方法（离线）固相微萃取与在线毛细管电泳（CE）样品富集技术相结合，用于分析水中样品中的酮洛芬，萘普生和氯纤维酸，这些被称为污染物在水生环境中日益引起关注。研究了基于色谱载体在环氧胶涂层针头上的物理偶联的新型固相微萃取纤维，用于这些微污染物的离线预浓缩。通过使用紫外二极管阵列检测（DAD）的毛细管区带电泳（CZE）对此类酸性药物进行鉴定和定量。通过在线CE“乙腈堆积”预浓缩技术，进一步提高了浓度灵敏度检测。在所研究的八种色谱载体中，Porapak Q吸附剂显示出更高的萃取和预浓缩能力。使用两级分数阶乘进行影响微萃取过程的参数筛选。然后通过表面响应三因素Box-Behnken设计完成最相关参数的优化。这三种药物的检出限和定量限分别在0.96和1.27μg？L？1和2.91和3.86μg？L？1之间。测量的回收率约为95％至104％。所开发的方法简单，精确，准确，并且可以使用廉价的纤维对Genil河水样品中的这些微量污染物进行定量。

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