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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas
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Effects of Octylphenol and Bisphenol A on the Metal Cation Transporter Channels of Mouse Placentas

机译：辛基酚和双酚A对小鼠胎盘金属阳离子转运通道的影响

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Octylphenol (OP) and bisphenol A (BPA) are known as endocrine-disrupting chemicals (EDCs). During pregnancy, the expression of steroid hormone receptors is controlled by maternal and fetal nutrition. To evaluate the impact of EDCs during pregnancy, ethinyl estradiol (EE, 0.2 mg/kg/day), OP (50 mg/kg/day), and BPA (50 mg/kg/day) were administered to pregnant mice. The mRNA levels of TRPV6 (transient receptor potential cation channels in subfamily V, member 6) decreased significantly by EE and OP. The PMCA1 (ATPase, Ca ++ transporting, plasma membrane 1) mRNA and protein levels decreased significantly by EE, OP, and BPA. CTR1 (solute carrier family 31, member 1) and ATP7A (ATPase, Cu ++ transporting, alpha polypeptide) expression decreased significantly by EE, OP, and BPA. The mRNA levels of IREG1 (iron-regulated transporter, member 1) decreased significantly by EE. Hephaestin (HEPH) mRNA levels decreased significantly by EE, OP, and BPA, and protein levels decreased significantly by BPA. As a result of immunohistochemistry analysis, all cation transporter proteins were found in labyrinth of placenta. To confirm the cytosolic level of cations, levels of cation level in fetal serum were measured. EE, OP, and BPA significantly reduced serum calcium and copper levels, and iron levels were reduced by BPA. Taken together, some EDCs, such as OP and BPA, could modulate the calcium, copper, and iron ion-transporting channels during pregnancy. The fetus relies on the mother for ionic transportation, and, therefore, pregnant women should avoid exposure to cation-channel-disrupting chemicals.
机译：辛基苯酚（OP）和双酚A（BPA）被称为破坏内分泌的化学物质（EDC）。怀孕期间，类固醇激素受体的表达受母体和胎儿营养的控制。为了评估EDC在怀孕期间的影响，对怀孕的小鼠给予了乙炔雌二醇（EE，0.2 mg / kg / day），OP（50 mg / kg / day）和BPA（50 mg / kg / day）。 EE和OP使TRPV6的mRNA水平（亚家族V中的瞬时受体电位阳离子通道，成员6）显着降低。 EE，OP和BPA使PMCA1（ATPase，Ca ++转运，质膜1）mRNA和蛋白水平显着降低。 EE，OP和BPA显着降低了CTR1（溶质载体家族31，成员1）和ATP7A（ATPase，Cu ++转运，α多肽）的表达。 EE使IREG1（铁调节转运蛋白，成员1）的mRNA水平显着下降。 EE，OP和BPA显着降低了肝素（HEPH）mRNA水平，BPA显着降低了蛋白水平。免疫组织化学分析的结果是，在胎盘的迷宫中发现了所有阳离子转运蛋白。为了确认阳离子的胞浆水平，测量了胎儿血清中的阳离子水平。 EE，OP和BPA显着降低了血清钙和铜水平，而BPA降低了铁水平。总体而言，某些EDC（例如OP和BPA）可以在怀孕期间调节钙，铜和铁离子的转运通道。胎儿依靠母亲进行离子运输，因此，孕妇应避免接触破坏阳离子通道的化学物质。

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