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首页> 外文期刊>International Journal of Environmental Research and Public Health >Assessing Diet as a Modifiable Risk Factor for Pesticide Exposure
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Assessing Diet as a Modifiable Risk Factor for Pesticide Exposure

机译：将饮食评估为可改变的农药暴露危险因素

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The effects of pesticides on the general population, largely as a result of dietary exposure, are unclear. Adopting an organic diet appears to be an obvious solution for reducing dietary pesticide exposure and this is supported by biomonitoring studies in children. However, results of research into the effects of organic diets on pesticide exposure are difficult to interpret in light of the many complexities. Therefore future studies must be carefully designed. While biomonitoring can account for differences in overall exposure it cannot necessarily attribute the source. Due diligence must be given to appropriate selection of participants, target pesticides and analytical methods to ensure that the data generated will be both scientifically rigorous and clinically useful, while minimising the costs and difficulties associated with biomonitoring studies. Study design must also consider confounders such as the unpredictable nature of chemicals and inter- and intra-individual differences in exposure and other factors that might influence susceptibility to disease. Currently the most useful measures are non-specific urinary metabolites that measure a range of organophosphate and synthetic pyrethroid insecticides. These pesticides are in common use, frequently detected in population studies and may provide a broader overview of the impact of an organic diet on pesticide exposure than pesticide-specific metabolites. More population based studies are needed for comparative purposes and improvements in analytical methods are required before many other compounds can be considered for assessment.
机译：目前尚不清楚农药主要是通过饮食暴露对普通人群的影响。采用有机饮食似乎是减少饮食中农药暴露的明显方法，这在儿童的生物监测研究中得到了支持。然而，鉴于许多复杂性，关于有机饮食对农药暴露影响的研究结果难以解释。因此，未来的研究必须精心设计。虽然生物监测可以解释总体暴露量的差异，但不一定能确定来源。尽职调查必须考虑到参与者，目标农药和分析方法的适当选择，以确保产生的数据将是既科学严谨和临床上有用，同时尽量减少与生物监测研究相关的成本和困难。研究设计还必须考虑混杂因素，例如化学品的不可预测性，个体之间和个体内部的暴露差异以及可能影响疾病易感性的其他因素。当前，最有用的措施是非特异性尿代谢物，可测量一系列有机磷酸酯和合成拟除虫菊酯类杀虫剂。这些农药是常用农药，在人口研究中经常被发现，与农药特定的代谢产物相比，有机饮食对农药暴露的影响可能具有更广泛的概述。为了进行比较，需要进行更多的基于人群的研究，并且在考虑其他许多化合物进行评估之前，还需要改进分析方法。

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