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首页> 外文期刊>International Journal of Environmental Research and Public Health >Histological Lesions, Cell Cycle Arrest, Apoptosis and T Cell Subsets Changes of Spleen in Chicken Fed Aflatoxin-contaminated Corn
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Histological Lesions, Cell Cycle Arrest, Apoptosis and T Cell Subsets Changes of Spleen in Chicken Fed Aflatoxin-contaminated Corn

机译：鸡饲喂黄曲霉毒素污染的玉米的组织学病变，细胞周期停滞，凋亡和脾脏T细胞亚群变化

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The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. A total of 900 COBB500 male broilers were randomly allocated into five groups with six replicates per group and 30 birds per replicate. The experiment lasted for 6 weeks and the five dietary treatments consisted of control, 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups. The histopathological spleen lesions from the contaminated corn groups was characterized as congestion of red pulp, increased necrotic cells and vacuoles in the splenic corpuscle and periarterial lymphatic sheath. The contaminated corn intake significantly increased relative weight of spleen, percentages of apoptotic splenocytes, induced cell cycle arrest of splenocytes, increased the percentages of CD3+CD8+ T cells and decreased the ratios of CD3+CD4+ to CD3+CD8+. The results suggest that AFB-induced immunosuppression maybe closely related to the lesions of spleen.
机译：这项研究的目的是评估天然被黄曲霉毒素B1和黄曲霉毒素B2污染的玉米对脾脏的病理病变，细胞凋亡，细胞周期阶段和T淋巴细胞亚群的影响，并为理解黄曲霉毒素诱导的机理提供实验依据。免疫抑制。将总共​​900头COBB500雄性肉鸡随机分为5组，每组6个重复，每重复30只。该实验持续了6周，五种饮食疗法包括对照组，25％的玉米污染，50％的玉米污染，75％的玉米污染和100％的玉米污染。来自受污染的玉米组的组织病理学脾脏病变的特征是脾脏小球和动脉周围淋巴鞘中的红髓充血，坏死细胞增多和液泡。受污染的玉米摄入显着增加了脾脏的相对重量，凋亡的脾细胞百分比，诱导的脾细胞细胞周期停滞，增加了CD3 + CD8 + T细胞的百分比并降低了CD3 + CD4 +与CD3 + CD8 +的比率。结果提示，AFB诱导的免疫抑制可能与脾脏病变密切相关。

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