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首页> 外文期刊>International Journal of Environmental Research and Public Health >Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
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Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome

机译：镉暴露对脂多糖与代谢综合征之间关联的影响

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摘要

Cadmium (Cd) is an environmental contaminant that has a direct impact on the gut microbiome. Perturbations in the gut microbiome have been linked to metabolic disorders associated with inflammation generated by lipopolysaccharide (LPS). We investigated the impact of Cd on the association between LPS and metabolic syndrome. The study population consisted of 200 apparently healthy subjects (30–64 years of age; 96 men, 104 women). Serum LPS and blood Cd concentrations were measured by ELISA and graphite furnace-atomic absorption spectrophotometry (GF-AAS), respectively. The highest LPS quartile was associated with a greater prevalence of metabolic syndrome in men. There was a significant association between LPS activity and metabolic syndrome in men with blood Cd concentrations higher than the 50th percentile (OR = 3.05, 95% CI = 1.39–6.70); however, this relationship was not significant in men with blood Cd concentrations lower than the 50th percentile. The results of this study provide evidence for a strong association between high LPS activity and the prevalence of metabolic syndrome in men with relatively high blood Cd concentrations. Therefore, exposure to Cd may potentiate the association between LPS and metabolic syndrome in men.
机译：镉（Cd）是一种环境污染物，对肠道微生物组具有直接影响。肠道微生物组中的扰动已与与脂多糖（LPS）产生的炎症相关的代谢紊乱有关。我们调查了镉对脂多糖和代谢综合征之间的关联的影响。研究人群包括200名看起来健康的受试者（30-64岁; 96名男性，104名女性）。分别通过ELISA和石墨炉原子吸收分光光度法（GF-AAS）测量血清LPS和血液Cd浓度。 LPS四分位数最高与男性代谢综合征患病率更高相关。血液中Cd浓度高于50％的男性中，LPS活性与代谢综合征之间存在显着相关性（OR = 3.05，95％CI = 1.39–6.70）。但是，在血液中Cd浓度低于50％的男性中，这种关系并不明显。这项研究的结果提供了证据，表明血液中Cd浓度相对较高的男性中，高LPS活性与代谢综合征的患病率之间存在很强的联系。因此，暴露于Cd可能会增强LPS与男性代谢综合征之间的联系。

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