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首页> 外文期刊>International Journal of Environmental Research and Public Health >A Murine Model to Study the Antibacterial Effect of Copper on Infectivity of Salmonella Enterica Serovar Typhimurium
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A Murine Model to Study the Antibacterial Effect of Copper on Infectivity of Salmonella Enterica Serovar Typhimurium

机译：研究铜对肠炎沙门氏菌鼠伤寒沙门氏菌感染性的小鼠模型

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摘要

This study investigated the effect of copper as an antibacterial agent on the infectivity of Salmonella enterica serovar Typhimurium. Mice were infected orally with a standardized dose of unstressed Salmonella Typhimurium and copper-stressed cells of Salmonella Typhimurium. Bacterial counts in ileum, blood, liver and spleen were observed up to 168 h under normal aerobic conditions. Serum sensitivity, phagocytosis, malondialdehyde levels and histopathology were studied for both set of animals. A decreased bacterial count in the organs with mild symptoms of infection and a complete recovery by 48 h was observed in mice infected with copper-stressed bacteria. Histopathological examination of ileum tissue demonstrated regeneration of damaged tissue post-infection with copper-stressed bacteria and no malondialdehyde levels were detected after 24 h in ileum, spleen and liver. Exposure to copper sensitized Salmonella Typhimurium to the lytic action of serum and intracellular killing by peritoneal macrophages. It can be concluded that copper stress confers a decrease in the infectivity of healthy Salmonella Typhimurium in normal mice. This study highlights the significance of use of copper as an antibacterial agent against Salmonella Typhimurium in reducing the risk of incidence of Salmonella infections from contaminated water.
机译：本研究调查了铜作为抗菌剂对肠炎沙门氏菌鼠伤寒沙门氏菌感染性的影响。口服标准剂量的鼠伤寒沙门氏菌和鼠伤寒沙门氏菌铜胁迫细胞感染小鼠。在正常的有氧条件下，回肠，血液，肝脏和脾脏中的细菌计数可长达168小时。研究了两组动物的血清敏感性，吞噬作用，丙二醛水平和组织病理学。在感染了铜胁迫细菌的小鼠中，观察到具有轻度感染症状的器官中细菌数量减少，并在48小时内完全恢复。回肠组织的组织病理学检查显示，受铜胁迫的细菌感染后受损组织的再生，在回肠，脾脏和肝脏中检测到24小时后未检测到丙二醛水平。暴露于铜致敏的鼠伤寒沙门氏菌对血清的溶解作用和腹膜巨噬细胞的杀伤作用。可以得出结论，铜应激使正常小鼠健康的鼠伤寒沙门氏菌的感染力降低。这项研究强调了使用铜作为针对鼠伤寒沙门氏菌的抗菌剂在降低受污染的水引起沙门氏菌感染的风险中的重要性。

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