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首页> 外文期刊>International Journal of Environmental Research and Public Health >Congenital Anomalies in Contaminated Sites: A Multisite Study in Italy
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Congenital Anomalies in Contaminated Sites: A Multisite Study in Italy

机译：受污染地点的先天性异常：意大利的一项多地点研究

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The health impact on populations residing in industrially contaminated sites (CSs) is recognized as a public health concern especially in relation to more vulnerable population subgroups. The aim of this study was to estimate the risk of congenital anomalies (CAs) in Italian CSs. Thirteen CSs covered by regional CA registries were investigated in an ecological study. The observed/expected ratios (O/E) with 90% confidence intervals (CI) for the total and specific subgroups of CAs were calculated using the regional areas as references. For the CSs with waste landfills, petrochemicals, and refineries, pooled estimates were calculated. The total number of observed cases of CAs was 7085 out of 288,184 births (prevalence 245.8 per 10,000). For some CSs, excesses for several CA subgroups were observed, in particular for genital and heart defects. The excess of genital CAs observed in Gela (O/E 2.36; 90% CI 1.73–3.15) is consistent with findings from other studies. For CSs including petrochemical and landfills, the pooled risk estimates were 1.10 (90% CI 1.01–1.19) and 1.07 (90% CI 1.02–1.13), respectively. The results are useful in identifying priority areas for analytical investigations and in supporting the promotion of policies for the primary prevention of CAs. The use of short-latency effect indicators is recommended for the health surveillance of the populations residing in CSs.
机译：对居住在工业污染场地（CSs）中的居民的健康影响被认为是公共卫生问题，尤其是与较脆弱的人口亚群相关的问题。这项研究的目的是评估意大利CS中先天性异常（CA）的风险。在一项生态研究中，调查了13个由地区CA注册管理机构覆盖的CS。使用区域区域作为参考，计算CA的全部和特定亚组的90％置信区间（CI）的观察/预期比率（O / E）。对于具有垃圾掩埋场，石化产品和炼油厂的CS，将计算汇总估计值。在288,184例分娩中，观察到的CA病例总数为7085（每10,000例患病率为245.8）。对于某些CS，观察到多个CA亚组的过量，特别是生殖器和心脏缺陷。在Gela中观察到的生殖器CA过量（O / E 2.36; 90％CI 1.73–3.15）与其他研究的结果一致。对于包括石化和垃圾填埋场的CS，合并风险估计分别为1.10（90％CI 1.01-1.19）和1.07（90％CI 1.02-1.13）。该结果对于确定分析研究的优先领域和支持促进CA一级预防政策的制定很有用。建议使用短时延效应指标对居住在CS中的人群进行健康监测。

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