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首页> 外文期刊>International Journal of Environmental Research and Public Health >Dyslipidaemia and Undernutrition in Children from Impoverished Areas of Maceió, State of Alagoas, Brazil
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Dyslipidaemia and Undernutrition in Children from Impoverished Areas of Maceió, State of Alagoas, Brazil

机译：巴西阿拉戈斯州Maceió贫困地区儿童的血脂异常和营养不良

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Chronic undernutrition causes reduced growth and endocrine adaptations in order to maintain basic life processes. In the present study, the biochemical profiles of chronically undernourished children were determined in order to test the hypothesis that chronic undernutrition also causes changes in lipid profile in pre-school children. The study population comprised 80 children aged between 12 and 71 months, including 60 with moderate undernutrition [height-for-age Z (HAZ) scores ≤ −2 and −3] and 20 with severe undernutrition (HAZ scores ≤ −3). Socioeconomic, demographic and environmental data were obtained by application of a questionnaire, and anthropometric measurements and information relating to sex, age and feeding habits were collected by a trained nutritionist. Blood samples were analysed for haemoglobin, vitamin A, insulin-like growth factor 1 (IGF-1) and serum lipids, while cortisol was assayed in the saliva. Faecal samples were submitted to parasitological investigation. Analysis of variance and χ2 methods were employed in order to select the variables that participated in the multivariate logistic regression analysis. The study population was socioeconomically homogeneous, while the lack of a treated water supply was clearly associated with the degree of malnutrition. Most children were parasitised and anaemia was significantly more prevalent among the severely undernourished. Levels of IGF-1 decreased significantly with increasing severity of undernutrition. Lipid analysis revealed that almost all of the children had dyslipidemia, while low levels of high-density lipoprotein were associated with the degree of undernutrition. It is concluded that chronic malnutrition causes endocrine changes that give rise to alterations in the metabolic profile of pre-school children.
机译：慢性营养不良会导致生长减少和内分泌适应不良，从而维持基本的生命过程。在本研究中，确定了慢性营养不良儿童的生化特征，以检验以下假设：慢性营养不良也会导致学龄前儿童脂质特征的变化。研究人群包括80名年龄在12到71个月之间的儿童，包括60名中度营养不良[Z-HAZ分数≤-2和> -3]和20名严重营养不良（HAZ分数≤-3）。通过问卷调查获得社会经济，人口和环境数据，并由训练有素的营养师收集人体测量数据以及与性别，年龄和喂养习惯有关的信息。分析血样中的血红蛋白，维生素A，胰岛素样生长因子1（IGF-1）和血清脂质，同时在唾液中测定皮质醇。粪便样本被送去进行寄生虫学调查。采用方差分析和χ 2 方法选择参与多元逻辑回归分析的变量。研究人群在社会经济上是同质的，而缺乏经过处理的供水显然与营养不良程度有关。大多数儿童患有寄生虫病，在严重营养不良的人群中，贫血的发生率明显更高。随着营养不良程度的增加，IGF-1的水平显着下降。脂质分析显示，几乎所有儿童都患有血脂异常，而低密度的高密度脂蛋白与营养不良程度有关。结论是，慢性营养不良会导致内分泌变化，导致学龄前儿童的代谢状况发生变化。

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