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首页> 外文期刊>International Journal of Environmental Research and Public Health >DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease
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DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease

机译：在环境和非酒精性脂肪肝界面的DNA羟甲基化

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Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide. Notwithstanding the known susceptibility factors for NAFLD, i.e., obesity and metabolic syndrome, the exact cause(s) of this disease and the underlying mechanisms of its initiation and progression are not fully elucidated. NAFLD is a multi-faceted disease with metabolic, genetic, epigenetic, and environmental determinants. Accumulating evidence shows that exposure to environmental toxicants contributes to the development of NAFLD by promoting mitochondrial dysfunction and generating reactive oxygen species in the liver. Imbalances in the redox state of the cells are known to cause alterations in the patterns of 5-hydroxymethylcytosine (5hmC), the oxidative product of 5-methylcytosine (5mC), thereby influencing gene regulation. The 5hmC-mediated deregulation of genes involved in hepatic metabolism is an emerging area of research in NAFLD. This review summarizes our current knowledge on the interactive role of xenobiotic exposure and DNA hydroxymethylation in the pathogenesis of fatty liver disease. Increasing the mechanistic knowledge of NAFLD initiation and progression is crucial for the development of new and effective strategies for prevention and treatment of this disease.
机译：在成人，儿童和青少年中，非酒精性脂肪肝疾病（NAFLD）是慢性肝病最普遍的形式之一，而且在世界范围内这种流行病也在不断增加。尽管已知对于NAFLD的易感性因素，即肥胖和代谢综合症，但尚未完全阐明该疾病的确切原因以及其起始和进展的潜在机制。 NAFLD是具有代谢，遗传，表观遗传和环境决定因素的多方面疾病。越来越多的证据表明，暴露于环境毒物中会促进线粒体功能障碍并在肝脏中产生活性氧，从而促进NAFLD的发展。已知细胞氧化还原状态的失衡会引起5-羟甲基胞嘧啶（5hmC）的氧化产物5-羟甲基胞嘧啶（5hmC）的模式改变，从而影响基因调控。 5hmC介导的肝代谢相关基因的失调是NAFLD研究的新兴领域。这篇综述总结了我们目前关于异源生物暴露和DNA羟甲基化在脂肪肝疾病发病机理中的相互作用的知识。增加NAFLD起始和进展的机制知识对于开发预防和治疗该疾病的新有效策略至关重要。

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