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首页> 外文期刊>International Journal of Environmental Research and Public Health >Higher Urinary Heavy Metal, Phthalate, and Arsenic but Not Parabens Concentrations in People with High Blood Pressure, U.S. NHANES, 2011–2012
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Higher Urinary Heavy Metal, Phthalate, and Arsenic but Not Parabens Concentrations in People with High Blood Pressure, U.S. NHANES, 2011–2012

机译：美国NHANES，2011-2012年，高血压人群的尿中重金属，邻苯二甲酸盐和砷含量较高，但对羟基苯甲酸酯含量未达到该水平

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摘要

Link between environmental chemicals and human health has emerged but not been completely examined in risk factors. Therefore, it was aimed to study the relationships of different sets of urinary environmental chemical concentrations and risk of high blood pressure (BP) in a national, population-based study. Data were retrieved from United States National Health and Nutrition Examination Surveys, 2011–2012 including demographics, BP readings, and urinary environmental chemical concentrations. Analyses included chi-square test, t-test and survey-weighted logistic regression modeling. After full adjustment (adjusting for urinary creatinine, age, sex, ethnicity, and body mass index), urinary cesium (OR 1.56, 95%CI 1.11–2.20, P = 0.014), molybden (OR 1.46, 95%CI 1.06–2.01, P = 0.023), manganese (OR 1.42, 95%CI 1.09–1.86, P = 0.012), lead (OR 1.58, 95%CI 1.28–1.96, P < 0.001), tin (OR 1.44, 95%CI 1.25–1.66, P < 0.001), antimony (OR 1.39, 95%CI 1.10–1.77, P = 0.010), and tungsten (OR 1.49, 95%CI 1.25–1.77, P < 0.001) concentrations were observed to be associated with high BP. People with higher urinary mono-2-ethyl-5-carboxypentyl phthalate (OR 1.33, 95%CI 1.00–1.62, P = 0.006), mono-n-butyl phthalate (OR 1.35, 95%CI 1.13–1.62, P = 0.002), mono-2-ethyl-5-hydroxyhexyl (OR 1.25, 95%CI 1.05–1.49, P = 0.014), mono-n-methyl phthalate (OR 1.26, 95%CI 1.07–1.48, P = 0.007), mono-2-ethyl-5-oxohexyl (OR 1.25, 95%CI 1.07–1.48, P = 0.009), and monobenzyl phthalate (OR 1.40, 95%CI 1.15–1.69, P = 0.002) tended to have high BP as well. However, there are no clear associations between environmental parabens and high BP, nor between pesticides and high BP. In addition, trimethylarsine oxide (OR 2.47, 95%CI 1.27–4.81, P = 0.011) and dimethylarsonic acid concentrations (OR 1.42, 95%CI 1.12–1.79, P = 0.006) were seen to be associated with high BP. In sum, urinary heavy metal, phthalate, and arsenic concentrations were associated with high BP, although the causal effect cannot be established from the current study design. Elimination of environmental chemicals in humans would still need to be continued.
机译：环境化学物质与人类健康之间的联系已经出现，但尚未对危险因素进行全面检查。因此，本研究旨在通过一项基于人群的全国性研究来研究不同组尿环境化学物浓度与高血压风险（BP）的关系。数据取自2011-2012年美国国家健康和营养调查，其中包括人口统计学，血压读数和尿中环境化学物质浓度。分析包括卡方检验，t检验和调查加权逻辑回归建模。完全调整（根据尿肌酐，年龄，性别，种族和体重指数进行调整）后，尿铯（OR 1.56，95 ％CI 1.11–2.20，P = 0.014），钼（OR 1.46，95 ％ CI 1.06–2.01，P = 0.023），锰（OR 1.42，95 ％CI 1.09–1.86，P = 0.012），铅（OR 1.58，95 ％CI 1.28–1.96，P <0.001），锡（或1.44、95 ％CI 1.25–1.66，P <0.001），锑（OR 1.39、95 ％CI 1.10–1.77，P = 0.010）和钨（或1.49、95 ％CI 1.25–1.77 （P <0.001）浓度与高BP相关。尿邻苯二甲酸单-2-乙基-5-羧基戊基酯含量较高的人（OR 1.33，95％CI 1.00–1.62，P = 0.006），邻苯二甲酸单正丁酯（OR 1.35，95％CI 1.13–1.62 ，P = 0.002），单-2-乙基-5-羟基己基（OR 1.25，95％CI 1.05-1.49，P = 0.014），邻苯二甲酸单正甲基酯（OR 1.26，95％CI 1.07–1.0， 1.48，P = 0.007），单-2-乙基-5-氧己基（OR 1.25，95％CI 1.07-1.48，P = 0.009）和邻苯二甲酸单苄酯（OR 1.40，95％CI 1.15-1.69， P = 0.002）也倾向于具有较高的BP。但是，在环境对羟基苯甲酸酯和高血压之间，农药与高血压之间没有明确的关联。此外，三甲基s氧化物（OR​​ 2.47，95％CI 1.27–4.81，P = 0.011）和二甲基ar酸浓度（OR 1.42，95％CI 1.12-1.79，P = 0.006）被认为与高BP。总之，虽然目前的研究设计无法确定因果关系，但尿中重金属，邻苯二甲酸盐和砷的浓度与高血压有关。仍然需要继续消除人类环境中的化学物质。

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