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首页> 外文期刊>International Journal of Environmental Research and Public Health >Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model
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Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

机译：使用人口毒代动力学模型估算甲基汞的生物半衰期

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Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values.
机译：众所周知，甲基汞会引起大脑和神经系统的不良健康影响。估算从血液或头发中甲基汞的生物半衰期得出的消除常数是计算甲基汞摄入量指南的重要部分。因此，本研究旨在评估韩国成年人中甲基汞的生物半衰期。我们使用一室模型，血液中甲基汞的浓度与饮食中甲基汞的日摄入量之间存在直接关系。我们对人群中甲基汞半衰期的人际差异进行了量化，并使用了信息量较高的先验估计模型中的参数。甲基汞的人口半衰期估计为80.2±8.6天。甲基汞半衰期的人口平均值为男性为81.6±8.4天，女性为78.9±8.6天。半衰期的标准偏差估计为25.0±8.6天。利用血液中甲基汞浓度与甲基汞摄入量之间的直接关系，估计该研究的生物学半衰期比用于设置准则值的早期研究所显示的更长。

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