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首页> 外文期刊>International Journal of Environmental Research and Public Health >Antenatal Dexamethasone Exposure in Preterm Infants Is Associated with Allergic Diseases and the Mental Development Index in Children
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Antenatal Dexamethasone Exposure in Preterm Infants Is Associated with Allergic Diseases and the Mental Development Index in Children

机译：早产儿地塞米松接触与过敏性疾病及儿童的心理发展指数有关

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Antenatal steroid administration may benefit fetal lung maturity in preterm infants. Although some studies have shown that this treatment may increase asthma in childhood, the correlation between antenatal dexamethasone exposure and allergic diseases remains unclear. The purpose of this study is to investigate the association between antenatal dexamethasone and T cell expression in childhood allergic diseases. Methods: We recruited a cohort of preterm infants born at Kaohsiung Chang Gung Memorial Hospital between 2007 and 2010 with a gestational age of less than 35 weeks and body weight at birth of less than 1500 g. The status of antenatal exposure to steroids and allergic diseases were surveyed using a modified ISAAC questionnaire for subjects aged 2–5 years old. We analyzed Th1/Th2/Th17 expression of mRNA, cytokines (using the Magpix? my-system), and mental development index (MDI). Results: Among the 40 patients that were followed, the data showed that the antenatal dexamethasone exposure group (N = 24) had a significantly higher incidence of allergic diseases (75.0% vs. 18.8%, p 0.05). However, the asthma group had higher IL-5 levels (p = 0.009), and the MDI was shown to be significantly higher in the dexamethasone exposure group (90.38 ± 3.31 vs. 79.94 ± 3.58, p = 0.043) while no significant difference was found between the PDI of the two groups. Conclusions: Exposure to antenatal dexamethasone in preterm infants will increase their susceptibility to allergic diseases, particularly asthma and allergic rhinitis. Preterm infants’ exposure to antenatal dexamethasone also results in higher MDI scores. Such increases in allergic diseases may be related to increased IL-5 and IL-10 levels.
机译：产前类固醇的给药可能有益于早产儿的胎儿肺成熟。尽管一些研究表明这种治疗方法可能会增加儿童期的哮喘病，但仍不清楚产前地塞米松暴露与过敏性疾病之间的相关性。这项研究的目的是调查儿童过敏性疾病中产前地塞米松与T细胞表达之间的关系。方法：我们招募了一组在2007年至2010年之间于高雄长庚纪念医院出生的早产儿，其胎龄小于35周，出生时体重小于1500 g。使用改良的ISAAC问卷调查了2至5岁受试者的产前暴露于类固醇和过敏性疾病的状况。我们分析了Th1 / Th2 / Th17 mRNA的表达，细胞因子（使用Magpix？my-system）和智力发育指数（MDI）。结果：在随访的40例患者中，数据显示，产前地塞米松暴露组（N = 24）的过敏性疾病发生率显着更高（75.0％，而18.8％，p <0.05）。但是，哮喘组的IL-5水平较高（p = 0.009），地塞米松暴露组的MDI值显着较高（90.38±3.31 vs. 79.94±3.58，p = 0.043），但无显着性差异。在两组的PDI之间找到。结论：早产儿接触产前地塞米松会增加他们对过敏性疾病的敏感性，特别是哮喘和过敏性鼻炎。早产儿接触产前地塞米松也会导致MDI得分更高。此类过敏性疾病的增加可能与IL-5和IL-10水平升高有关。

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