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首页> 外文期刊>International Journal of Environmental Research and Public Health >Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk
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Associations of Breast Cancer Risk Factors with Premenopausal Sex Hormones in Women with Very Low Breast Cancer Risk

机译：乳腺癌风险极低的女性中乳腺癌危险因素与绝经前性激素的相关性

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Breast cancer incidence rates are low but rising in urban Mongolia. We collected reproductive and lifestyle factor information and measured anthropometrics and serum sex steroid concentrations among 314 premenopausal women living in Ulaanbaatar, Mongolia. Mean differences in hormone concentrations by these factors were calculated using age-adjusted quadratic regression splines. Estrone and estradiol in college-educated women were, respectively, 18.2% (p = 0.03) and 23.6% (p = 0.03) lower than in high-school-educated women. Progesterone concentrations appeared 55.8% lower (p = 0.10) in women residing in modern housing compared with women living in traditional housing (gers), although this finding was not statistically significant.?Testosterone concentrations were positively associated with adiposity and central fat distribution; 17.1% difference (p = 0.001) for highest vs. lowest quarter for body mass index and 15.1% difference (p = 0.005) for waist-to-height ratio. Estrogens were higher in the follicular phase of women who breastfed each child for shorter durations. A distinct hormonal profile was associated with an urban lifestyle in premenopausal, Mongol women. In particular, heavier, more-educated women living in urban dwellings had higher testosterone and lower estrogen and progesterone levels. Higher breast cancer incidence in urban compared with rural women suggest that the hormonal profile associated with a more traditional lifestyle may be protective among Mongol women.
机译：蒙古城市的乳腺癌发病率较低，但正在上升。我们收集了生殖和生活方式因素的信息，并测量了居住在蒙古乌兰巴托的314名绝经前妇女的人体测量学和血清性类固醇浓度。使用年龄调整后的二次回归样条计算这些因素引起的激素浓度的平均差异。受过大学教育的女性中的雌酮和雌二醇分别比受过高中教育的女性低18.2％（p = 0.03）和23.6％（p = 0.03）。与传统住所（gers）居住的妇女相比，居住在现代住所中的妇女的孕酮浓度降低了55.8％（p = 0.10），尽管这一发现在统计学上并不显着。睾丸激素浓度与肥胖和中央脂肪分布呈正相关;体重指数最高和最低四分之一的差异为17.1％（p = 0.001），而腰高比差异为15.1％（p = 0.005）。母乳喂养每个孩子时间较短的妇女的卵泡期雌激素水平较高。蒙古绝经前妇女的独特激素特征与都市生活方式有关。特别是，生活在城市住宅中的重度，高学历妇女的睾丸激素水平更高，雌激素和孕激素水平更低。与农村妇女相比，城市妇女的乳腺癌发病率更高，这表明与更传统生活方式相关的荷尔蒙特征可能对蒙古族妇女具有保护作用。

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