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首页> 外文期刊>International Journal of Environmental Research and Public Health >Acute Anterior Uveitis as a Risk Factor of Ankylosing Spondylitis—A National Population-Based Study
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Acute Anterior Uveitis as a Risk Factor of Ankylosing Spondylitis—A National Population-Based Study

机译：急性前葡萄膜炎是强直性脊柱炎的危险因素-一项基于全国人口的研究

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Introduction: In clinical settings, acute anterior uveitis (AAU) could be the first presentation of ankylosing spondylitis (AS). Based on this hypothesis, we investigate whether AAU is a risk factor in developing AS later by using National Health Insurance Research Database (NHIRD) in Taiwan. Materials and Methods: This cohort comparison study used longitudinal Taiwanese NHIRD to probe the relative risk odds of AAU for AS development, and consisted of all patients diagnosed with AAU (n = 5621) (ICD-9-CM codes 364.00). The relative risks of AS between AAU patients and controls were compared by estimating the crude hazard ratio with logistic regression. Kaplan–Meier analysis was used to calculate the cumulative incidence rates of developing AS, and a log-rank test was used to analyze the differences between the survival curves. Separate Cox proportional hazard regressions were performed to compute the AS-free rate after adjusting for possible confounding factors such as age and sex. Results: The crude hazard ratio was 2.667 for the AAU group, and the adjusted hazard ratio was 2.705 for the AAU group. The observation time of the AS-free group was shorter for AAU patients compared with the control group (1507 versus 1578 days). Moreover, in the AAU patients, the younger age onset of AAU (less than 30 years old here) would lead to an earlier diagnosis of AS later with a median of 1445.5 (742–2241) versus 1544 (819–2289) days of survival for the group of age onset of AAU greater than 30 years old. The difference is statistically significant ( p < 0.05). Conclusions: AAU was a risk factor for AS. To identify AAU as an extra-articular manifestation is crucial for early diagnosis and treatment of AS and containing functional loss accordingly.
机译：简介：在临床环境中，急性前葡萄膜炎（AAU）可能是强直性脊柱炎（AS）的首例表现。基于此假设，我们通过使用台湾国家健康保险研究数据库（NHIRD），调查了AAU是否是稍后发展AS的危险因素。资料和方法：这项队列比较研究使用纵向台湾NHIRD来探讨AAU发生AS发育的相对风险几率，并包括所有诊断为AAU的患者（n = 5621）（ICD-9-CM代码364.00）。通过逻辑回归估计粗风险比，比较了AAU患者和对照组之间AS的相对风险。 Kaplan–Meier分析用于计算发展中的AS的累积发生率，对数秩检验用于分析生存曲线之间的差异。在对可能的混杂因素（例如年龄和性别）进行调整后，进行了独立的Cox比例风险回归以计算无AS发生率。结果：AAU组的原始危险比为2.667，AAU组的调整后危险比为2.705。与对照组相比，AAU患者的无AS组的观察时间更短（1507对1578天）。此外，在AAU患者中，较年轻的AAU发病年龄（此处小于30岁）将导致AS的早期诊断，其中位生存时间为1445.5（742–2241）天，而存活时间为1544（819-2289）天对于AAU发病年龄大于30岁的人群。差异具有统计学意义（p <0.05）。结论：AAU是AS的危险因素。确定AAU为关节外表现对于AS的早期诊断和治疗以及相应地包含功能丧失至关重要。

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