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首页> 外文期刊>International Journal of Environmental Research and Public Health >Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphorus Pesticides: National Health and Nutrition Examination Survey 1999–2004
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Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphorus Pesticides: National Health and Nutrition Examination Survey 1999–2004

机译：尿中有机磷农药的磷酸二烷基酯代谢物的浓度：1999-2004年美国国家健康和营养调查

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Organophosphorus (OP) insecticides were among the first pesticides that EPA reevaluated as part of the Food Quality Protection Act of 1996. Our goal was to assess exposure to OP insecticides in the U.S. general population over a six-year period. We analyzed 7,456 urine samples collected as part of three two-year cycles of the National Health and Nutrition Examination Survey (NHANES) from 1999–2004. We measured six dialkylphosphate metabolites of OP pesticides to assess OP pesticide exposure. In NHANES 2003–2004, dimethylthiophosphate was detected most frequently with median and 95th percentile concentrations of 2.03 and 35.3 μg/L, respectively. Adolescents were two to three times more likely to have diethylphosphate concentrations above the 95th percentile estimate of 15.5 μg/L than adults and senior adults. Conversely, for dimethyldithiophosphate, senior adults were 3.8 times and 1.8 times more likely to be above the 95th percentile than adults and adolescents, respectively, while adults were 2.1 times more likely to be above the 95th percentile than the adolescents. Our data indicate that the most vulnerable segments of our population—children and older adults—have higher exposures to OP pesticides than other population segments. However, according to DAP urinary metabolite data, exposures to OP pesticides have declined during the last six years at both the median and 95th percentile levels.
机译：有机磷（OP）杀虫剂是EPA根据1996年《食品质量保护法》重新评估的首批农药之一。我们的目标是评估六年内美国普通人群对OP杀虫剂的接触情况。我们分析了1999-2004年作为国家健康与营养检查调查（NHANES）的三个两年周期的一部分而收集的7,456份尿液样本。我们测量了OP农药的六种磷酸二烷基酯代谢物，以评估OP农药的暴露量。在NHANES 2003-2004中，最常检测到二甲基硫代磷酸二甲酯，其中位数和第95个百分浓度分别为2.03和35.3μg/ L。青少年的磷酸二乙酯浓度高于95％的估计值15.5μg/ L的可能性是成年人和老年人的2至3倍。相反，对于二甲基二硫代磷酸酯，高于95％的成年人的成人分别比成年人和青少年高3.8倍和1.8倍，而高于95％的成年人的可能性比青少年高2.1倍。我们的数据表明，我们人口中最脆弱的部分（儿童和老年人）比其他人口部分的OP农药暴露量更高。但是，根据DAP尿液代谢产物的数据，在过去六年中，OP农药的中位数和第95个百分位数水平均下降了。

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