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首页> 外文期刊>International Journal of Environmental Research and Public Health >Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure
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Levels of Pesticides and Their Metabolites in Wistar Rat Amniotic Fluids and Maternal Urine upon Gestational Exposure

机译：妊娠暴露后Wistar大鼠羊水和母体尿液中农药及其代谢物的水平

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摘要

Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
机译：在将Wistar大鼠口服给予两种由三至五种农药组成的农药混合物（比色林，丙环唑，氯氰菊酯，马拉硫磷和丁丁嗪）后，测定大鼠尿液和羊水中农药和选定代谢产物的浓度作为生物标志物。在大鼠羊水和尿液中发现了农药及其代谢产物，通常其剂量-反应浓度与剂量有关。羊水中物质的测量表明，胎儿已暴露于农药及其代谢产物中。此外，尿液中检测到的农药证明了其暴露能力以及大鼠排泄这些化合物的能力。

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