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首页> 外文期刊>International Journal of Environmental Science and Toxicology >Combined exposure of di(2-ethylhexyl) phthalate, dibutyl phthalate and acetyl tributylcitrate: toxic effects on the growth and reproductive system of zebra fish (Danio rerio)
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Combined exposure of di(2-ethylhexyl) phthalate, dibutyl phthalate and acetyl tributylcitrate: toxic effects on the growth and reproductive system of zebra fish (Danio rerio)

机译：邻苯二甲酸二（2-乙基己基）酯，邻苯二甲酸二丁酯和柠檬酸乙酰基三丁酯的联合暴露：对斑马鱼（Danio rerio）生长和生殖系统的毒性影响

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This study examined the growth and reproductive toxicity of combined plasticizer mixture of two phthalate esters of di(2-ethylhexyl) phthalate (DEHP) anddibutyl phthalate (DBP)and one phthalate substitute of acetyl tributyl citrate (ATBC) to adult zebrafish after three-month exposure at an environmentally relevant concentration (50 μg/L). Obtained data demonstrated significant adverse effects on the growth and reproductive system of adult zebrafish, as evidenced by significant decrease in body lengths, weight and gonado-somatic index, impairment of fecundity, disruption of oogenesis and spermatogenesis, etc. Male zebrafish were more sensitive to the combined exposure with respect to relatively lower fecundity and testis in male were damaged more than the female ovariesobserved. The maturation of oocytes was inhibited as evidenced by more underdeveloped perinucleolar and early cortical alveolar oocytes as well as atretic oocytes in the exposed ovary. In contrast, most of the spermatocysts were broken and almost all of the spermatogenetic cells of spermatogonia, spermatocytes andspermatids were lost in the exposed testis, inferring that Sertoli cells might be the main target cells of the combined plasticizer mixture and subsequent infertility of the exposed male fish. Thus great concerns should be raised on the reproductive safety of aquatic organisms when exposed to combined plasticizer mixture.
机译：这项研究研究了三个月后的邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸二丁酯（DBP）的一种邻苯二甲酸酯和一种邻苯二甲酸柠檬酸三丁酯（ATBC）的组合增塑剂混合物对成年斑马鱼的生长和生殖毒性。在与环境有关的浓度（50μg/ L）下暴露。获得的数据表明，对成年斑马鱼的生长和生殖系统有严重的不利影响，如体长，体重和性腺体指数的显着降低，生殖力受损，卵子发生和精子发生中断等所证明。雄性斑马鱼对斑马鱼更敏感。在男性中，相对较低的生殖力和睾丸的综合暴露受到的损害要大于女性卵巢。卵母细胞的成熟受到抑制，如裸露的卵巢中更多的不发达的核仁和早期皮质肺泡卵母细胞以及闭锁卵母细胞所证明。相反，在暴露的睾丸中，大多数精子囊被破坏，几乎所有的精原细胞，精子细胞和精子细胞都丢失，这表明Sertoli细胞可能是合并的增塑剂混合物的主要靶细胞，并随后暴露了雄性的不育症。鱼。因此，当暴露于混合的增塑剂混合物中时，应引起对水生生物生殖安全的极大关注。

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