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首页> 外文期刊>International Journal of Environmental Research and Public Health >Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine
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Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine

机译：四种内分泌干扰物对小脑细胞培养物中雌激素受体β转录的个体和联合作用的比较：雌二醇和三碘甲状腺素的调节作用

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摘要

Humans and animals are continuously exposed to a number of environmental substances that act as endocrine disruptors (EDs). While a growing body of evidence is available to prove their adverse health effects, very little is known about the consequences of simultaneous exposure to a combination of such chemicals; Methods: Here, we used an in vitro model to demonstrate how exposure to bisphenol A, zearalenone, arsenic, and 4-methylbenzylidene camphor, alone or in combination, affect estrogen receptor β (ERβ) mRNA expression in primary cerebellar cell cultures. Additionally, we also show the modulatory role of intrinsic biological factors, such as estradiol (E2), triiodo-thyronine (T3), and glial cells, as potential effect modulators; Results: Results show a wide diversity in ED effects on ERβ mRNA expression, and that the magnitude of these ED effects highly depends on the presence or absence of E2, T3, and glial cells; Conclusion: The observed potency of the EDs to influence ERβ mRNA expression, and the modulatory role of E2, T3, and the glia suggests that environmental ED effects may be masked as long as the hormonal milieu is physiological, but may tend to turn additive or superadditive in case of hormone deficiency.
机译：人和动物不断暴露于多种环境物质中，这些物质起内分泌干扰物（ED）的作用。尽管有越来越多的证据证明它们对健康有不利影响，但人们对同时接触这些化学物质的后果知之甚少。方法：在这里，我们使用体外模型来证明单独或组合使用双酚A，玉米赤霉烯酮，砷和4-甲基亚苄基樟脑如何影响原代小脑细胞培养物中雌激素受体β（ERβ）mRNA表达。此外，我们还显示出内在生物学因素（如雌二醇（E2），三碘甲状腺素（T3）和神经胶质细胞）的调节作用，作为潜在的效应调节剂。结果：结果表明，ED对ERβmRNA表达的影响差异很大，而这些ED的程度在很大程度上取决于E2，T3和神经胶质细胞的存在与否。结论：观察到的EDs影响ERβmRNA表达的能力以及E2，T3和神经胶质的调节作用表明，只要荷尔蒙环境是生理性的，环境ED的作用就可以被掩盖，但可能会加成或激素缺乏时使用超级添加剂。

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