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首页> 外文期刊>International Journal of Environmental Research and Public Health >Alcohol and Acetaldehyde in Public Health: From Marvel to Menace
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Alcohol and Acetaldehyde in Public Health: From Marvel to Menace

机译：公共卫生中的酒精和乙醛：从奇迹到威胁

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摘要

Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and social problems. In addition, genetic susceptibility to the effect of alcohol on cancer and coronary heart disease differs across the population. A number of mechanisms including direct the toxicity of ethanol, its metabolites [e.g., acetaldehyde and fatty acid ethyl esters (FAEEs)] and oxidative stress may mediate alcoholic complications. Acetaldehyde, the primary metabolic product of ethanol, is an important candidate toxin in developing alcoholic diseases. Meanwhile, free radicals produced during ethanol metabolism and FAEEs are also important triggers for alcoholic damages.
机译：酗酒是一个严重的医学和社会问题。尽管轻度至中度饮酒有益于心血管健康，但大量饮酒通常会导致器官损害和社会问题。此外，人群对酒精对癌症和冠心病影响的遗传易感性也有所不同。许多机制包括直接影响乙醇，其代谢产物（例如，乙醛和脂肪酸乙基酯（FAEEs））的毒性和氧化应激可能介导酒精中毒并发症。乙醛是乙醇的主要代谢产物，是发展酒精性疾病的重要候选毒素。同时，乙醇代谢过程中产生的自由基和FAEE也是导致酒精损害的重要诱因。

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