...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Environmental Research and Public Health >Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies
【24h】

Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies

机译：内分泌干​​扰化学物质和子宫内膜癌：最近的实验室证据和流行病学研究概述

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background : Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women’s health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Until recently, there were relatively few epidemiological studies examining the relationship between EDCs and endometrial cancer, however, in the last years the number of these studies has increased. Methods : A systematic MEDLINE (PubMed) search was performed and relevant articles published in the last 23 years (from 1992 to 2016) were selected. Results : Human studies and animal experiments are confirming a carcinogenic effect due to the EDC exposure and its carcinogenesis process result to be complex, multifactorial and long standing, thus, it is extremely difficult to obtain the epidemiological proof of a carcinogenic effect of EDCs for the high number of confusing factors. Conclusions : The carcinogenic effects of endocrine disruptors are plausible, although additional studies are needed to clarify their mechanisms and responsible entities. Neverthless, to reduce endocrine disruptors (ED) exposure is mandatory to implement necessary measures to limit exposure, particularly during those periods of life most vulnerable to the impact of oncogenic environmental causes, such as embryonic period and puberty.
机译：背景：尽管已建议接触内分泌干扰物（EDC）是导致一系列女性健康疾病的因素，包括不育，多囊卵巢和青春期的早发，但在将因果关系归因于妇科癌症方面仍存在相当大的挑战。直到最近，很少有流行病学研究检查EDC与子宫内膜癌之间的关系，但是，在最近几年中，这些研究的数量有所增加。方法：进行系统的MEDLINE（PubMed）搜索，并选择最近23年（1992年至2016年）发表的相关文章。结果：人体研究和动物实验证实，由于暴露于EDC的致癌作用，其致癌过程复杂，多因素，长期存在，因此，很难获得EDC致癌的流行病学证据。大量令人困惑的因素。结论：内分泌干扰物的致癌作用是合理的，尽管还需要进一步的研究来阐明其机制和负责任的实体。但是，必须减少内分泌干扰物（ED）的暴露，以实施必要的措施来限制暴露，特别是在那些最容易受到致癌环境原因影响的生命时期，例如胚胎期和青春期。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号