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首页> 外文期刊>International Journal of Environmental Research and Public Health >Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?
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Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?

机译：蚊子控制的基因驱动器：它来自哪里，我们去哪里？

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摘要

Mosquito-borne pathogens place an enormous burden on human health. The existing toolkit is insufficient to support ongoing vector-control efforts towards meeting disease elimination and eradication goals. The perspective that genetic approaches can potentially add a significant set of tools toward mosquito control is not new, but the recent improvements in site-specific gene editing with CRISPR/Cas9 systems have enhanced our ability to both study mosquito biology using reverse genetics and produce genetics-based tools. Cas9-mediated gene-editing is an efficient and adaptable platform for gene drive strategies, which have advantages over innundative release strategies for introgressing desirable suppression and pathogen-blocking genotypes into wild mosquito populations; until recently, an effective gene drive has been largely out of reach. Many considerations will inform the effective use of new genetic tools, including gene drives. Here we review the lengthy history of genetic advances in mosquito biology and discuss both the impact of efficient site-specific gene editing on vector biology and the resulting potential to deploy new genetic tools for the abatement of mosquito-borne disease.
机译：蚊子传播的病原体给人类健康带来巨大负担。现有工具包不足以支持正在进行的病媒控制工作，以实现疾病消除和根除的目标。遗传方法可能会为蚊子控制添加大量工具的观点并不是什么新观点，但是利用CRISPR / Cas9系统对位点特异性基因编辑的最新改进增强了我们利用反向遗传学研究蚊子生物学并产生遗传学的能力。基于工具。 Cas9介导的基因编辑是基因驱动策略的高效且适应性强的平台，相对于将期望的抑制和病原体阻断基因型渗入野生蚊子种群的无穷释放策略而言，它具有优势。直到最近，有效的基因驱动还远远不够。许多考虑因素将指导有效使用新的遗传工具，包括基因驱动。在这里，我们回顾了蚊子生物学遗传学发展的漫长历史，并讨论了有效的针对特定位点的基因编辑对媒介生物学的影响以及由此产生的潜在潜力，以部署新的遗传工具来减轻蚊媒疾病。

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