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首页> 外文期刊>International Journal of Environmental Research and Public Health >Effects of Dietary Selenium on Histopathological Changes and T Cells of Spleen in Broilers Exposed to Aflatoxin B1
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Effects of Dietary Selenium on Histopathological Changes and T Cells of Spleen in Broilers Exposed to Aflatoxin B1

机译：日粮硒对黄曲霉毒素B1暴露的肉仔鸡组织病理变化及脾脏T细胞的影响

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摘要

Aflatoxin B1 (AFB1), which causes hepatocellular carcinoma and immune-suppression, is commonly found in feedstuffs. To evaluate the ability of selenium (Se) to counteract the deleterious effects of AFB1, two hundred 1-day-old male avian broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB1 (AFB1 group), 0.3 mg/kg AFB1+0.2 mg/kg Se (+Se group I), 0.3 mg/kg AFB1+0.4 mg/kg Se (+Se group II) and 0.3 mg/kg AFB1+0.6 mg/kg Se (+Se group III), respectively. Compared with control group, the relative weight of spleen in the AFB1 group was decreased at 21 days of age. The relative weight of spleen in the three +Se groups was higher than that in the AFB1 group. By pathological observation, the major spleen lesions included congestion in red pulp and vacuoles appeared in the lymphatic nodules and periarterial lymphatic sheath in the AFB1 group. In +Se groups II and III, the incidence of major splenic lesions was decreased. The percentages of CD3+, CD3+CD4+ and CD3+CD8+ T cells in the AFB1 group were lower than those in control group from 7 to 21 days of age, while there was a marked increase in the three +Se groups compared to the AFB1 group. The results indicated that sodium selenite could improve the cellular immune function impaired by AFB1 through increasing the relative weight of spleen and percentages of splenic T cell subsets, and alleviating histopathological spleen damage.
机译：黄曲霉毒素B1（AFB1）会引起肝细胞癌和免疫抑制，常见于饲料中。为了评估硒（Se）抵抗AFB1有害作用的能力，将200只1天大的雄性肉鸡分为5组，分别饲喂基础饮食（对照组），0.3 mg / kg AFB1（AFB1）组），0.3 mg / kg AFB1 + 0.2 mg / kg Se（+ Se组I），0.3 mg / kg AFB1 + 0.4 mg / kg Se（+ Se组II）和0.3 mg / kg AFB1 + 0.6 mg / kg Se （+ Se第三类）。与对照组相比，AFB1组的脾脏相对体重在21日龄时有所降低。三个+ Se组的脾脏相对体重均高于AFB1组。通过病理观察，AFB1组的主要脾脏病变包括红髓充血，并且在淋巴结节和动脉周围淋巴鞘中出现液泡。在+ Se组II和III中，主要脾脏病变的发生率降低了。 7至21天时，AFB1组的CD3 +，CD3 + CD4 +和CD3 + CD8 + T细胞百分比低于对照组，而三个+ Se组比AFB1组显着增加。结果表明，亚硒酸钠可通过增加脾脏的相对重量和脾脏T细胞亚群的百分比，减轻组织病理学对脾脏的损害来改善AFB1损害的细胞免疫功能。

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