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首页> 外文期刊>International Journal of Environmental Research and Public Health >Pediatric Exposure to Drugs of Abuse by Hair Testing: Monitoring 15 Years of Evolution in Spain
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Pediatric Exposure to Drugs of Abuse by Hair Testing: Monitoring 15 Years of Evolution in Spain

机译：通过头发测试，儿科接触滥用药物的情况：监测西班牙15年的演变

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Hair testing is a useful tool to investigate the prevalence of unsuspected chronic exposure to drugs of abuse in pediatric populations and it has been applied to three different cohorts of children from Barcelona, Spain along fifteen years to evaluate eventual changes in this exposure. Children were recruited from three independent studies performed at Hospital del Mar (Barcelona, Spain) and approved by the local Ethics Committee. Hair samples were collected from the first 187 children cohort (around 4 years of age) in 1998, from the second 90 children cohort (1.5–5 years of age) in 2008 and from the third 114 children cohort (5–14 years of age) in 2013. Hair samples were analysed for the presence of opiates, cocaine, amphetamines, and cannabis by validated methodologies using gas or liquid chromatography-mass spectrometry. Familiar sociodemographics and eventual consumption of drugs of abuse by parents, and caregivers were recorded. Hair samples from 24.6% children in 1998 were positive for any drug of abuse (23.0% cocaine), 25.5% in 2008 (23.3% cocaine), and 28.1% in 2013 (20.1% cocaine and 11.4% cannabis). In none of the cohorts, parental sociodemographics were associated with children exposure to drugs of abuse. The results of the three study cohorts demonstrated a significant prevalence of unsuspected pediatric exposure to drugs of abuse which mainly involved cocaine maintained along fifteen years in Barcelona, Spain. We recommend to be aware about unsuspected passive exposure to drugs of abuse in general population and to use general or selected hair screening to disclose exposure to drugs of abuse in children from risky environments to provide the basis for specific social and health interventions.
机译：头发测试是一种有用的工具，可用于调查儿童人群中未曾怀疑的长期暴露于滥用药物的情况，并将其应用于十五年来来自西班牙巴塞罗那的三组不同的儿童中，以评估这种暴露的最终变化。儿童是从在德尔马医院（西班牙巴塞罗那）进行的三项独立研究中招募而来，并得到当地伦理委员会的批准。从1998年的前187个儿童队列（约4岁），2008年的后90个儿童队列（1.5至5岁）和第114个儿童队列（5至14岁）中收集了头发样本。 ）在2013年。采用验证的方法，使用气相色谱或液相色谱-质谱法分析了头发样品中的鸦片，可卡因，苯丙胺和大麻。记录了熟悉的社会人口统计资料，并最终记录了父母和看护人滥用药物的情况。 1998年，来自24.6％儿童的头发样本中的任何滥用药物均为阳性（可卡因23.0％），2008年为25.5％（可卡因23.3％）和2013年为28.1％（可卡因20.1％和大麻11.4％）。在这两个队列中，没有一个父母的社会人口统计学与儿童受到滥用药物的影响有关。这三个研究队列的结果表明，未经怀疑的儿科儿童滥用滥用药物的患病率很高，主要涉及西班牙巴塞罗那长达15年的可卡因维持情况。我们建议要注意一般人群中未经怀疑的被动滥用药物的情况，并使用常规或选择性的头发筛查来揭示危险环境中儿童滥用药物的暴露情况，从而为特定的社会和健康干预措施提供依据。

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