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首页> 外文期刊>International Journal of Environmental Research and Public Health >Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality
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Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

机译：与吸烟和内部空气质量相关的上班族的氧化应激

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Studies have used 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker to detect systemic oxidative DNA damage associated with oxidative stress. However, studies on the association between exposure to tobacco smoking and urinary 8-OHdgG give inconsistent results. Limited studies have estimated the oxidative stress among office workers. This study assessed the association between urinary 8-OHdG and cotinine for office workers.? Workers (389) including smokers, ex-smokers and non-smokers from 87 offices at high-rise buildings in Taipei participated in this study with informed consent. Each participant completed a questionnaire and provided a spot urine specimen at the end of work day for measuring urinary 8-OHdG and cotinine. The carbon dioxide (CO2) levels in workers’ offices were also measured. The questionnaire reported socio-demographic characteristics, life styles and allergic history. The urinary 8-OHdG level increased with the cotinine level among participants (Spearmans’ rho = 0.543, p < 0.001). The mean of urinary 8-OHdG and cotinine was 5.81 ± 3.53 μg/g creatinine and 3.76 ± 4.06 μg/g creatinine, respectively. Comparing with non-smokers, the adjusted odds ratio (OR) of having urinary 8-OHdG greater than the median level of 4.99 μg/g creatinine was 5.30 (95% confidence intervals (CI) = 1.30–21.5) for current smokers and 0.91 (95% CI = 0.34–2.43) for former smokers. We also found workers exposed to 1,000 ppm of CO2 at offices had an adjusted OR of 4.28 (95% CI = 1.12–16.4) to have urinary 8-OHdG greater than 4.99 μg/g creatinine, compared to those exposed to indoor CO2 under 600 ppm. In conclusion, urinary 8-OHdG could represent a suitable marker for measuring smoking and CO2 exposure for office workers.
机译：研究已使用8-羟基脱氧鸟苷（8-OHdG）作为生物标记物来检测与氧化应激相关的全身性氧化DNA损伤。但是，关于吸烟暴露与尿中8-OHdgG之间关系的研究结果不一致。有限的研究估计了上班族的氧化压力。这项研究评估了上班族尿液中的8-OHdG与可替宁之间的关系。来自台北高层建筑的87个办公室的吸烟者，前吸烟者和不吸烟者等工人（389）在知情同意下参加了这项研究。每位参与者填写一份调查表，并在工作日结束时提供尿液样本以测量尿中的8-OHdG和可替宁。还测量了工人办公室中的二氧化碳（CO2）水平。该问卷报告了社会人口统计学特征，生活方式和过敏史。参与者的尿中8-OHdG水平随可替宁水平升高而升高（Spearmans rho = 0.543，p <0.001）。尿中的8-OHdG和可替宁的平均值分别为5.81±3.53μg/ g肌酐和3.76±4.06μg/ g肌酐。与非吸烟者相比，当前吸烟者尿中8-OHdG高于中位数水平4.99μg/ g肌酐的调整后的优势比（OR）为5.30（95％置信区间（CI）= 1.30–21.5）前吸烟者为0.91（95％CI = 0.34-2.43）。我们还发现，与暴露于室内CO2的工人相比，暴露于办公室1,000 ppm CO2的工人的校正OR值为4.28（95％CI = 1.12-16.4），尿中的8-OHdG大于4.99μg/ g肌酐。低于600 ppm。总之，尿中的8-OHdG可能是衡量上班族吸烟和CO2暴露的合适标志物。

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