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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Protective Effect of Gangliosides on Lead (Pb)-Induced Neurotoxicity Is Mediated by Autophagic Pathways
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The Protective Effect of Gangliosides on Lead (Pb)-Induced Neurotoxicity Is Mediated by Autophagic Pathways

机译：自噬途径介导神经节苷脂对铅（Pb）诱导的神经毒性的保护作用。

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摘要

Lead (Pb) is a ubiquitous environmental and industrial pollutant and can affect intelligence development and the learning ability and memory of children. Therefore, necessary measures should be taken to protect the central nervous system (CNS) from Pb toxicity. Gangliosides are sialic acid-containing glycosphingolipids that are constituents of mammalian cell membranes and are more abundantly expressed in the CNS. Studies have shown that gangliosides constitute a useful tool in the attempt to promote functional recovery of CNS and can reverse Pb-induced impairments of synaptic plasticity in rats. However, the detailed mechanisms have yet to be fully understood. In our present study, we tried to investigate the role of gangliosides in Pb-induced injury in hippocampus neurons and to further confirm the detailed mechanism. Our results show that Pb-induced injuries in the spatial reference memory were associated with a reduction of cell viability and cell apoptosis, and treatment with gangliosides markedly ameliorated the Pb-induced injury by inhibition of apoptosis action. Gangliosides further attenuated Pb-induced the abnormal autophagic process by regulation of mTOR pathways. In summary, our study establishes the efficacy of gangliosides as neuroprotective agents and provides a strong rationale for further studies on the underlying mechanisms of their neuroprotective functions.
机译：铅（Pb）是一种普遍存在的环境和工业污染物，可影响智力发展以及儿童的学习能力和记忆力。因此，应采取必要的措施以保护中枢神经系统（CNS）免受铅的毒性。神经节苷脂是含有唾液酸的鞘糖脂，是哺乳动物细胞膜的组成部分，在CNS中表达更为丰富。研究表明，神经节苷脂是促进中枢神经系统功能恢复的有效工具，可逆转铅诱导的大鼠突触可塑性损伤。但是，详细的机制尚未完全理解。在本研究中，我们试图研究神经节苷脂在铅诱导的海马神经元损伤中的作用，并进一步证实其详细机制。我们的结果表明，空间参考记忆中铅诱导的损伤与细胞活力和细胞凋亡的降低有关，神经节苷脂治疗通过抑制细胞凋亡作用显着改善了铅诱导的损伤。神经节苷脂通过调节mTOR途径进一步减弱了Pb诱导的异常自噬过程。总之，我们的研究确立了神经节苷脂作为神经保护剂的功效，并为进一步研究其神经保护功能的潜在机制提供了有力的依据。

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