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首页> 外文期刊>International Journal of Environmental Research and Public Health >Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism and Diabetic Retinopathy—A Meta-Analysis Comprising 10,168 Subjects
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Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism and Diabetic Retinopathy—A Meta-Analysis Comprising 10,168 Subjects

机译：血管紧张素转换酶（ACE）基因多态性与糖尿病性视网膜病变之间的关联—包含10,168名受试者的荟萃分析

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Aims—to address the inconclusive findings of the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods—we conducted a meta-analysis on 4252 DR cases and 5916 controls from 40 published studies by searching electronic databases and reference lists of relevant articles. A random-effects or fixed-effects model was used to estimate the overall and stratification effect sizes on ACE I/D polymorphism on the risk of DR. Results—we found a significant association between the ACE I/D polymorphism and the risk of DR for all genetic model (ID vs. II: OR = 1.14, 95% CI: 1.00–1.30; DD vs. II: OR = 1.38, 95% CI: 1.11–1.71; Allele contrast: OR = 1.17, 95% CI: 1.05–1.30; recessive model: OR = 1.24, 95% CI: 1.02–1.51 and dominant model: OR = 1.21, 95% CI: 1.06–1.38, respectively). In stratified analysis by ethnicity and DM type, we further found that the Asian group with T2DM showed a significant association for all genetic models (ID vs. II: OR = 1.14, 95% CI: 1.01–1.30; DD vs. II: OR = 1.54, 95% CI: 1.14–2.08; Allele contrast: OR = 1.26, 95% CI: 1.09–1.47; recessive model: OR = 1.42, 95% CI: 1.07–1.88 and dominant model: OR = 1.26, 95% CI: 1.07–1.49, respectively). Conclusion—our study suggested that the ACE I/D polymorphism may contribute to DR development, especially in the Asian group with type 2 diabetes mellitus (T2DM). Prospective and more genome-wide association studies (GWAS) are needed to clarify the real role of the ACE gene in determining susceptibility to DR.
机译：目的—为了解决血管紧张素转换酶（ACE）插入/缺失（I / D）多态性与糖尿病性视网膜病变（DR）风险相关的不确定性结果，进行了荟萃分析。方法-我们通过搜索电子数据库和相关文章的参考清单，对40篇已发表研究的4252例DR病例和5916例对照进行了荟萃分析。使用随机效应或固定效应模型来估计ACE I / D多态性对DR风险的总体和分层效应大小。结果-我们发现ACE I / D多态性与所有遗传模型的DR风险之间存在显着关联（ID与II：OR = 1.14，95％CI：1.00-1.30; DD与II：OR = 1.38， 95％CI：1.11-1.71;等位基因对比：OR = 1.17，95％CI：1.05-1.30;隐性模型：OR = 1.24，95％CI：1.02-1.51和显性模型：OR = 1.21，95％CI：1.06 –1.38）。在按种族和DM类型进行的分层分析中，我们进一步发现，患有T2DM的亚洲人群对所有遗传模型均显示出显着关联（ID与II：OR = 1.14，95％CI：1.01-1.30; DD与II：OR = 1.54，95％CI：1.14–2.08;等位基因对比：OR = 1.26，95％CI：1.09–1.47;隐性模型：OR = 1.42，95％CI：1.07-1.88，显性模型：OR = 1.26，95％ CI：分别为1.07-1.49）。结论—我们的研究表明ACE I / D多态性可能有助于DR的发展，特别是在亚洲2型糖尿病（T2DM）组中。需要前瞻性和更多的全基因组关联研究（GWAS）来阐明ACE基因在确定对DR的敏感性中的真正作用。

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