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首页> 外文期刊>International Journal of Environmental Research and Public Health >In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids
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In Vitro Investigations of Human Bioaccessibility from Reference Materials Using Simulated Lung Fluids

机译：使用模拟肺液从参考材料中进行人体生物可及性的体外研究

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An investigation for assessing pulmonary bioaccessibility of metals from reference materials is presented using simulated lung fluids. The objective of this paper was to contribute to an enhanced understanding of airborne particulate matter and its toxic potential following inhalation. A large set of metallic elements (Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, and Zn) was investigated using three lung fluids (phosphate-buffered saline, Gamble’s solution and artificial lysosomal fluid) on three standard reference materials representing different types of particle sources. Composition of the leaching solution and four solid-to-liquid (S/L) ratios were tested. The results showed that bioaccessibility was speciation- (i.e., distribution) and element-dependent, with percentages varying from 0.04% for Pb to 86.0% for Cd. The higher extraction of metallic elements was obtained with the artificial lysosomal fluid, in which a relative stability of bioaccessibility was observed in a large range of S/L ratios from 1/1000 to 1/10,000. For further investigations, it is suggested that this method be used to assess lung bioaccessibility of metals from smelter-impacted dusts.
机译：提出了使用模拟的肺液评估金属从参考材料的肺生物可及性的研究。本文的目的是帮助人们更好地理解空气中的颗粒物及其吸入后的潜在毒性。使用三种标准的三种肺液（磷酸盐缓冲液，Gamble's溶液和人工溶酶体液）研究了大量金属元素（Ba，Cd，Co，Cr，Cu，Mn，Ni，Pb，Sr和Zn）代表不同类型颗粒源的参考材料。测试了浸出溶液的组成和四个固液比（S / L）。结果表明，生物可及性是物种形成的（即分布）和元素依赖性的，百分比范围从Pb的0.04％到Cd的86.0％不等。用人工溶酶体液获得较高的金属元素提取率，其中在1/1000至1 / 10,000的较大S / L比范围内观察到生物可及性的相对稳定性。为了进一步研究，建议将该方法用于评估熔炉撞击粉尘中金属的肺生物可及性。

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