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首页> 外文期刊>International Journal of Environmental Research and Public Health >Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen
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Association of Bisphenol A Exposure with LINE-1 Hydroxymethylation in Human Semen

机译：双酚A暴露与人精液中LINE-1羟甲基化的关系

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Bisphenol A (BPA), an exogenous endocrine-disrupting chemical, has been shown to alter DNA methylation. However, little information is available about the effect of BPA exposure on DNA hydroxymethylation in humans. The objective of the present study was to examine whether BPA exposure was associated with DNA hydroxymethylation in human semen samples. We measured urine BPA levels and LINE-1 hydroxymethylation in 158 male factory workers selected from an occupational cohort study conducted in China between 2004 and 2008. Among them, there were 72 male workers with occupational BPA exposure (BPA-exposed group) and 86 male workers without occupational BPA exposure (unexposed group). Multivariate linear regression models were used to examine the association of exposure to BPA with LINE-1 hydroxymethylation. LINE-1 was more highly hydroxymethylated in the BPA-exposed group than in the unexposed group (median 12.97% vs. 9.68%, respectively; p 0.05), after adjusting for the potential confounders. The medians of 5-hydroxymethylcytosine (5hmC) generally increased with increasing urine BPA levels: 8.79%, 12.16%, 11.53%, and 13.45%, for undetected BPA and corresponding tertiles for the detected BPA, respectively. After analysis using data at individual level, our findings indicated that BPA exposure was associated with alterations of sperm LINE-1 hydroxymethylation, which might have implications for understanding the mechanisms underlying BPA-induced adverse effects on male reproductive function.
机译：双酚A（BPA）是一种外源性破坏内分泌的化学物质，已显示可改变DNA甲基化。但是，关于BPA暴露对人类DNA羟甲基化的影响的信息很少。本研究的目的是检查人精液样品中BPA暴露是否与DNA羟甲基化有关。我们测量了2004年至2008年间在中国进行的一项职业队列研究中选出的158名男性工厂工人的尿液BPA水平和LINE-1羟甲基化。其中，有72名男性工人接受了职业BPA暴露（BPA暴露组），其中86名男性没有职业BPA暴露的工人（未暴露组）。多变量线性回归模型用于检验BPA暴露与LINE-1羟甲基化的关系。在调整了潜在的混杂因素后，BPA暴露组的LINE-1羟甲基化程度高于未暴露组（分别为12.97％和9.68％;中位数，分别为p <0.05）。 5-羟甲基胞嘧啶（5hmC）的中位数通常随着尿液BPA水平的升高而增加：未检测到的BPA分别为8.79％，12.16％，11.53％和13.45％。使用个人水平的数据进行分析后，我们的发现表明BPA暴露与精子LINE-1羟甲基化的改变有关，这可能有助于理解BPA诱导的对男性生殖功能的不良影响的机制。

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