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首页> 外文期刊>International Journal of Environmental Research and Public Health >Comments on Rithidech, K.N.; et al. Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation. Int. J. Environ. Res. Public Health 2013, 10, 1356–1377
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Comments on Rithidech, K.N.; et al. Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation. Int. J. Environ. Res. Public Health 2013, 10, 1356–1377

机译：评论关于Rithidech，K.N .;等。 SCID小鼠骨髓细胞缺乏基因组不稳定性，使全身暴露于低剂量辐射。诠释J.环境。 Res。公共卫生2013，10，1356–1377

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I would like to take issue with Rithidech et al., authors of the paper entitled “Lack of genomic instability in mice at low doses” [1] who claim to have shown that their results on the measurement of late occurring chromosome aberrations after irradiation of SCID mice with X-rays show that lower doses (0.05 Gy) do not induce genomic instability. Their earlier work at higher doses (0.1 and 1.0 Gy) on the same strain of mouse indicated that de novo chromosome aberrations were detected at 6 months post-irradiation. This was taken, almost certainly correctly, to be an indication of the presence of genomic instability: late appearing chromosome damage, as the authors note, seems to be a reliable indicator of the process. The lack of de novo chromosome aberrations at 6 months post-irradiation, however, cannot be taken as evidence of the absence of genomic instability. In drawing their conclusion of a “lack of genomic instability ….” the authors have committed two category errors.
机译：我想对Rithidech等人的论文《低剂量的小鼠缺乏基因组不稳定性》 [1]的作者提出质疑，他们声称已经证明了他们对放射线照射后晚期染色体畸变的测量结果。带有X射线的SCID小鼠显示，较低剂量（0.05 Gy）不会引起基因组不稳定。他们在同一个小鼠品系上以较高剂量（0.1和1.0 Gy）进行的早期工作表明，在辐照后6个月检测到新生染色体畸变。几乎可以肯定地说，这被认为是基因组不稳定性的征兆：如作者所指出的，较晚出现的染色体损伤似乎是该过程的可靠指标。但是，辐照后6个月缺乏从头染色体畸变，不能被视为缺乏基因组不稳定性的证据。在得出“缺乏基因组不稳定性……”的结论时。作者犯了两个类别错误。

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